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Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus

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dc.creatorCastaño-Rodríguez, Nataliaspa
dc.creatorDiaz-Gallo, Lina-Marcelaspa
dc.creatorPineda-Tamayo, Ricardospa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:17Z
dc.date.available2020-05-26T00:01:17Z
dc.date.created2008spa
dc.description.abstractObjective: To estimate the common effect size of HLA-DRB1 and -DQB1 alleles on systemic lupus erythematosus (SLE) susceptibility across Latin America populations through a meta-analysis. Methods: Case-control studies on HLA class II association with SLE in Latin America were searched up to August 2007. The effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: Eleven studies were selected, which included 747 cases and 1180 controls. Associations with SLE susceptibility were found for HLA-DR2 (OR: 1.75; 95% CI: 1.40-2.19) and -DR3 (OR: 2.02; 95% CI: 1.44-2.83) groups. HLA-DRB1*0301 allele disclosed the strongest association (OR: 2.14; 95% CI: 1.28-3.56). HLA-DR3-DQ2 haplotype was a risk factor (OR: 2.92; 95% CI: 1.66-5.14). A protective effect was found for the HLA-DR5 group (OR: 0.43; 95% CI: 0.27-0.67), mainly due to a negative association between HLA-DRB1*1101 allele and disease (OR: 0.21; 95% CI: 0.06-0.72). Functional analysis of susceptibility and protective alleles revealed physicochemical differences of critical amino acids shaping the peptide-binding groove at DR? chain allowing us to infer an approach to understand the role of HLA in SLE. No significant association was established for HLA-DQB1 alleles. Conclusions: HLA-DRB1 gene is a mayor factor for development of SLE in Latin Americans. © 2007 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2007.12.002
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23345
dc.language.isoengspa
dc.relation.citationEndPage330
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage322
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 7
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.7, No.4 (2008); pp. 322-330spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-39549090421&doi=10.1016%2fj.autrev.2007.12.002&partnerID=40&md5=342255e8cd3d1ebf62ff827a2100dc27spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmino acidspa
dc.subject.keywordgeneticeng
dc.subject.keywordsystemiceng
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordPeptidespa
dc.subject.keywordAllelespa
dc.subject.keywordCase control studyspa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordControlled studyspa
dc.subject.keywordData extractionspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPhysical chemistryspa
dc.subject.keywordReviewspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordStatistical analysisspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdultspa
dc.subject.keywordAllelesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHla-dq antigensspa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMiddle agedspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordHla antigens/allelesspa
dc.subject.keywordHla haplotypesspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleMeta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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