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Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.

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dc.creatorMeneses-Echavez, Jose Fspa
dc.creatorRamírez-Vélez, Robinson
dc.creatorCorrea Bautista, Jorge Enriquespa
dc.date.accessioned2020-08-06T16:24:05Z
dc.date.available2020-08-06T16:24:05Z
dc.date.created2015-05-20spa
dc.descriptionBackground: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-? (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.spa
dc.description.abstractBackground: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-? (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.spa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1200/jco.2015.33.15_suppl.e12581
dc.identifier.issnISSN: 0732-183X
dc.identifier.issnEISSN: 1527-7755
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26450
dc.language.isoengspa
dc.publisherAmerican Society of Clinical Oncologyspa
dc.relation.citationEndPagee12581
dc.relation.citationIssueNo. 15_suppl
dc.relation.citationStartPagee12581
dc.relation.citationTitleJournal of Clinical Oncology
dc.relation.citationVolumeVol. 33
dc.relation.ispartofJournal of Clinical Oncology, ISSN: 0732-183X ; EISSN:1527-7755, Vol.33, No.15_suppl (2015); pp.e12581-e12581spa
dc.relation.urihttps://ascopubs.org/doi/10.1200/jco.2015.33.15_suppl.e12581spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceJournal of Clinical Oncologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordBreast cancerspa
dc.subject.keywordOncology and Carcinogenesisspa
dc.subject.keywordExercise trainingspa
dc.titleLow-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.spa
dc.title.TranslatedTitleInflamación de bajo grado y entrenamiento físico en mujeres con cáncer de mama: un metanálisis con metarregresión.spa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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