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Eficacia y seguridad de la melatonina para el manejo de los trastornos del sueño en el autismo: meta-análisis

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dc.contributor.advisorIbáñez Pinilla, Milcíades
dc.contributor.advisorVallejo Silva, Alexie
dc.creatorRodríguez T., María del Rosario
dc.creatorMéndez Álvarez, Liliana P.
dc.creatorJairo M., González Díaz
dc.creator.degreeEspecialista en Psiquiatría
dc.date.accessioned2016-03-07T22:23:26Z
dc.date.available2016-03-07T22:23:26Z
dc.date.created2016-02-01
dc.date.issued2016
dc.descriptionINTRODUCCIÓN: El 80% de los niños y adolescentes con trastornos del espectro autista (TEA) presenta algún trastorno del sueño, en cuya génesis al parecer intervienen alteraciones en la regulación de la melatonina. El objetivo de este metaanálisis fue determinar la eficacia y seguridad de la melatonina para el manejo de ciertos trastornos del sueño en niños con TEA. MÉTODOS: Tres revisores extrajeron los datos relevantes de los ensayos clínicos aleatorizados doble ciego de alta calidad publicados en bases de datos primarias, de ensayos clínicos, de revisiones sistemáticas y de literatura gris; además se realizó búsqueda en bola de nieve. Se analizaron los datos con RevMan 5.3. Se realizó un análisis del inverso de la varianza por un modelo de efectos aleatorios para las diferencias de medias de los desenlaces propuestos: duración del tiempo total, latencia de sueño y número de despertares nocturnos. Se evaluó la heterogeneidad interestudios con el parámetro I2 RESULTADOS: La búsqueda inicial arrojó 355 resultados, de los cuales tres cumplieron los criterios de selección. La melatonina resultó ser un medicamento seguro y eficaz para aumentar la duración total del sueño y disminuir la latencia de sueño en niños y adolescentes con TEA; hasta el momento la evidencia sobre el número de despertares nocturnos no es estadísticamente significativa. DISCUSIÓN: A la luz de la evidencia disponible, la melatonina es una elección segura y eficaz para el manejo de ciertos problemas del sueño en niños y adolescentes con TEA. Es necesario realizar estudios con mayores tamaños muestrales y comparados con otros medicamentos disponibles en el mercado.spa
dc.description.abstractINTRODUCTION: Up to 80% of children and adolescents with autism spectrum disorders (ASD) has a sleep disorder, in whose genesis some alterations in the regulation of melatonin are apparently involved. The aim of this meta-analysis was to determine the efficacy and safety of melatonin for management of certain sleep disorders in children with ASD. METHODS: Three reviewers extracted relevant data from high-quality double-blind randomized clinical trials published in primary, clinical trials, systematic reviews and gray literature databases; further search was conducted in snowball. Data were analyzed with RevMan 5.3. An inverse of variance analysis by random-effects model was made for the mean differences of the proposed outcomes was performed (total sleep time, sleep onset latency and number of nighttime awakenings). Inter-study heterogeneity was evaluated with I2 parameter. RESULTS: The initial search yielded 355 results, of which three met the selection criteria. Melatonin was found to be a safe and effective drug to increase total sleep time and decrease sleep onset latency in children and adolescents with ASD; so far the evidence on the number of night awakenings is not statistically significant. DISCUSSION: According to available evidence, melatonin is a safe and effective choice for managing certain sleep problems in children and adolescents with ASD. Studies are needed with larger sample sizes and comparing with other drugs available in the market.eng
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dc.identifier.doihttps://doi.org/10.48713/10336_11837
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/11837
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Psiquiatríaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
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dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectAutismospa
dc.subjectMelatoninaspa
dc.subjectTrastornos del Sueñospa
dc.subject.ddcEnfermedades
dc.subject.decsPsicoanálisisspa
dc.subject.decsTrastorno autísticospa
dc.subject.decsTrastornos del sueñospa
dc.subject.decsMelatoninaspa
dc.subject.keywordAutismeng
dc.subject.keywordMelatonineng
dc.subject.keywordSleep Disorderseng
dc.subject.lembPsiquiatríaspa
dc.titleEficacia y seguridad de la melatonina para el manejo de los trastornos del sueño en el autismo: meta-análisisspa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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