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The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris

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dc.creatorMisas E.spa
dc.creatorEscandón P.spa
dc.creatorMcEwen J.G.spa
dc.creatorClay O.K.spa
dc.date.accessioned2020-05-25T23:58:37Z
dc.date.available2020-05-25T23:58:37Z
dc.date.created2019spa
dc.description.abstractThe LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Societyeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/pro.3727
dc.identifier.issn9618368
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22895
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage2029
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage2024
dc.relation.citationTitleProtein Science
dc.relation.citationVolumeVol. 28
dc.relation.ispartofProtein Science, ISSN:9618368, Vol.28, No.11 (2019); pp. 2024-2029spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073583103&doi=10.1002%2fpro.3727&partnerID=40&md5=1b07a6c81973d183c7e0031fcb9c40c4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordRegulator proteinspa
dc.subject.keywordSingle stranded dna binding proteinspa
dc.subject.keywordTranscription factorspa
dc.subject.keywordArticlespa
dc.subject.keywordCandida aurisspa
dc.subject.keywordDrug resistancespa
dc.subject.keywordFungal virulencespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein structurespa
dc.subject.keywordStructure analysisspa
dc.subject.keywordTranscription initiationspa
dc.subject.keywordTranscription regulationspa
dc.subject.keywordActivation and repression domainsspa
dc.subject.keywordAmphotericin bspa
dc.subject.keywordAntifungal resistance mechanismsspa
dc.subject.keywordCandidaspa
dc.subject.keywordFilamentation in fungispa
dc.subject.keywordFlocculencespa
dc.subject.keywordLufs domainspa
dc.subject.keywordSingle nucleotide polymorphismsspa
dc.subject.keywordTranscription factorsspa
dc.subject.keywordWhole-genome sequence comparisonsspa
dc.titleThe LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida aurisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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