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An epidemiological and molecular study regarding the spread of vancomycin-resistant Enterococcus faecium in a teaching hospital in Bogotá, Colombia 2016

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dc.creatorCorredor, Nancy Carolinaspa
dc.creatorLópez, Carolinaspa
dc.creatorAguilera, Paula Andreaspa
dc.creatorPrieto, Lina Maríaspa
dc.creatorRodriguez-Leguizamon, Giovanni
dc.creatorLeal, Aura Lucíaspa
dc.creatorOvalle-Guerro, María Victoriaspa
dc.creatorPardo Oviedo, Juan Mauriciospa
dc.creatorChica, Claudia Elenaspa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-05-26T00:03:08Z
dc.date.available2020-05-26T00:03:08Z
dc.date.created2019spa
dc.description.abstractBackground: Enterococcus faecium is ranked worldwide as one of the top ten pathogens identified in healthcare-associated infections (HAI) and is classified as one of the high priority pathogens for research and development of new antibiotics worldwide. Due to molecular biology techniques' higher costs, the approach for identifying and controlling infectious diseases in developing countries has been based on clinical and epidemiological perspectives. Nevertheless, after an abrupt vancomycin-resistant Enterococcus faecium dissemination in the Méderi teaching hospital, ending up in an outbreak, further measures needed to be taken into consideration. The present study describes the vancomycin-resistant Enterococcus faecium pattern within Colombian's largest installed-bed capacity hospital in 2016. Methods: Thirty-three vancomycin-resistant Enterococcus faecium isolates were recovered during a 5-month period in 2016. Multilocus variable-number tandem-repeat analysis was used for molecular typing to determine clonality amongst strains. A modified time-place-sequence algorithm was used to trace VREfm spread patterns during the outbreak period and estimate transmission routes. Results: Four clonal profiles were identified. Chronological clonal profile follow-up suggested a transitional spread from profile 'A' to profile 'B', returning to a higher prevalence of 'A' by the end of the study. Antibiotic susceptibility indicated high-level vancomycin-resistance in most isolates frequently matching vanA gene identification. Discussion: Transmission analysis suggested cross-contamination via healthcare workers. Despite epidemiological control of the outbreak, post-outbreak isolates were still being identified as having outbreak-related clonal profile (A), indicating reduction but not eradication of this clonality. This study supports the use of combined molecular and epidemiological strategies in an approach to controlling infectious diseases. It contributes towards a more accurate evaluation of the effectiveness of the epidemiological measures taken regarding outbreak control and estimates the main cause related to the spread of this microorganism. © 2019 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12879-019-3877-7
dc.identifier.issn14712334
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23565
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Infectious Diseases
dc.relation.citationVolumeVol. 19
dc.relation.ispartofBMC Infectious Diseases, ISSN:14712334, Vol.19, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85062963788&doi=10.1186%2fs12879-019-3877-7&partnerID=40&md5=6aecd5f3866c9d5cefee6ccc78d3a87espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntibiotic sensitivityspa
dc.subject.keywordteachingeng
dc.subject.keywordArticlespa
dc.subject.keywordBacterial genespa
dc.subject.keywordBacterial strainspa
dc.subject.keywordBacterial transmissionspa
dc.subject.keywordBacterium contaminationspa
dc.subject.keywordBacterium isolatespa
dc.subject.keywordClinical articlespa
dc.subject.keywordClonal variationspa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDescriptive researchspa
dc.subject.keywordDisease surveillancespa
dc.subject.keywordEnterococcus faeciumspa
dc.subject.keywordEpidemicspa
dc.subject.keywordGene identificationspa
dc.subject.keywordGenetic algorithmspa
dc.subject.keywordHospital infectionspa
dc.subject.keywordHumanspa
dc.subject.keywordMolecular dynamicsspa
dc.subject.keywordMolecular typingspa
dc.subject.keywordNonhumanspa
dc.subject.keywordObservational studyspa
dc.subject.keywordPhenotypespa
dc.subject.keywordPrevalencespa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordSequence analysisspa
dc.subject.keywordTeaching hospitalspa
dc.subject.keywordVana genespa
dc.subject.keywordVancomycin resistant enterococcusspa
dc.subject.keywordVariable number of tandem repeatspa
dc.subject.keywordBacterium identificationspa
dc.subject.keywordClassificationspa
dc.subject.keywordDrug effectspa
dc.subject.keywordEnterococcus faeciumspa
dc.subject.keywordEpidemicspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGram positive infectionspa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordMicrobial sensitivity testspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMultilocus sequence typingspa
dc.subject.keywordTeaching hospitalspa
dc.subject.keywordTransmissionspa
dc.subject.keywordVancomycin resistant enterococcusspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordBacterial proteinspa
dc.subject.keywordVancomycinspa
dc.subject.keywordAnti-bacterial agentsspa
dc.subject.keywordBacterial proteinsspa
dc.subject.keywordBacterial typing techniquesspa
dc.subject.keywordColombiaspa
dc.subject.keywordDisease outbreaksspa
dc.subject.keywordEnterococcus faeciumspa
dc.subject.keywordGram-positive bacterial infectionsspa
dc.subject.keywordHospitalseng
dc.subject.keywordHumansspa
dc.subject.keywordMicrobial sensitivity testsspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMultilocus sequence typingspa
dc.subject.keywordVancomycinspa
dc.subject.keywordVancomycin-resistant enterococcispa
dc.subject.keywordAntimicrobial resistancespa
dc.subject.keywordOutbreak surveillancespa
dc.subject.keywordTime-place-sequence algorithmspa
dc.subject.keywordVancomycin-resistant enterococcus faeciumspa
dc.titleAn epidemiological and molecular study regarding the spread of vancomycin-resistant Enterococcus faecium in a teaching hospital in Bogotá, Colombia 2016spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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