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p53 and its role in the ovarian surface epithelium. A review

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dc.creatorChuaire-Noack L.spa
dc.creatorSánchez-Corredor M.C.spa
dc.creatorRamírez Clavijo, Sandra Rocíospa
dc.date.accessioned2020-05-25T23:55:42Z
dc.date.available2020-05-25T23:55:42Z
dc.date.created2008spa
dc.description.abstractThe ovarian surface epithelium (OSE) is a single layer of cells subject to a high rate of turnover at he site of follicular rupture at ovulation and this results in a higher risk of malignant cell transformation. Findings like cancer derived from OSE, that accounts for approximately 90% of all human ovarian malignancies and the frequent mutations of the p53 gen in most of them, are the basis for reviewing OSE structure and histogenesis related to p53, as well as some aspects associated with p53 stabilization and regulation, its involvement in key events like cell cycle arrest, induction of apoptosis, etiology and pathogenesis of epithelial ovarian cancer. Finally, this review takes into account recent farmacogenetics advances in order to use p53 as a target. in the therapy against cancer.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn5355133
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22185
dc.language.isoengspa
dc.relation.citationEndPage593
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage563
dc.relation.citationTitleInvestigacion Clinica
dc.relation.citationVolumeVol. 49
dc.relation.ispartofInvestigacion Clinica, ISSN:5355133, Vol.49, No.4 (2008); pp. 563-593spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-61549141358&partnerID=40&md5=a918d6799d11428357c5e4115eb38681spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCyclin dependent kinase inhibitor 1spa
dc.subject.keywordp53eng
dc.subject.keywordGrowth arrest and dna damage inducible protein 45spa
dc.subject.keywordProtein baxspa
dc.subject.keywordProtein p53spa
dc.subject.keywordProtein p53spa
dc.subject.keywordApoptosisspa
dc.subject.keywordCell cycle arrestspa
dc.subject.keywordCell structurespa
dc.subject.keywordGene mutationspa
dc.subject.keywordHistogenesisspa
dc.subject.keywordHumanspa
dc.subject.keywordOvary cancerspa
dc.subject.keywordOvary cellspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein stabilityspa
dc.subject.keywordReviewspa
dc.subject.keywordCell differentiationspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordCytologyspa
dc.subject.keywordEpitheliumspa
dc.subject.keywordFemalespa
dc.subject.keywordGeneticsspa
dc.subject.keywordMetabolismspa
dc.subject.keywordOvaryspa
dc.subject.keywordOvary tumorspa
dc.subject.keywordPathologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordTumor suppressor genespa
dc.subject.keywordCell differentiationspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordEpitheliumspa
dc.subject.keywordFemalespa
dc.subject.keywordGeneseng
dc.subject.keywordHumansspa
dc.subject.keywordOvarian neoplasmsspa
dc.subject.keywordOvaryspa
dc.subject.keywordTumor suppressor protein p53spa
dc.subject.keywordApoptosisspa
dc.subject.keywordCell cyclespa
dc.subject.keywordCell signalingspa
dc.subject.keywordChemotherapyspa
dc.subject.keywordEpithelial ovarian cancerspa
dc.subject.keywordHistogenesisspa
dc.subject.keywordPathogenesisspa
dc.titlep53 and its role in the ovarian surface epithelium. A reviewspa
dc.title.TranslatedTitlep53 y su papel en el epitelio superficial del ovario. Revisiónspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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