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Evaluating the effect of sarconesiopsis magellanica (Diptera: Calliphoridae) larvae-derived haemolymph and fat body extracts on chronic wounds in diabetic rabbits

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dc.creatorGóngora, Jennifher
dc.creatorDíaz Roa, Andrea
dc.creatorRamírez Hernández, Alejandro
dc.creatorCortés-Vecino, Jesús A.
dc.creatorGaona-Cifuentes, María Antonia
dc.creatorPatarroyo, Manuel A.
dc.creatorBello, Felio
dc.creator.googleGóngora, Jnniferspa
dc.creator.googleDíaz-Roa, Andreaspa
dc.creator.googleRamírez-Hernández, Alejandrospa
dc.creator.googleCortés-Vecino, Jesús A.spa
dc.creator.googleGaona, María A.spa
dc.creator.googlePatarroyo, Manuel A.spa
dc.creator.googleBello, Feliospa
dc.date.accessioned2020-04-16T02:51:57Z
dc.date.available2020-04-16T02:51:57Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractWe evaluated extracts taken from S. magellanica third instar larvae fat body and haemolymph using a diabetic rabbit model and compared this to the effect obtained with the same substances taken from Lucilia sericata larvae. Alloxan (a toxic glucose analogue) was used to induce experimental diabetes in twelve rabbits. Dorsal wounds were made in each animal and they were infected with Staphylococcus aureus and Pseudomonas aeruginosa. They were then treated with haemolymph and lyophilized extracts taken from the selected blowflies' larvae fat bodies. Each wound was then evaluated by using rating scales and histological analysis. More favourable scores were recorded on the PUSH and WBS scales for the wounds treated with fat body derived from the larvae of both species compared to that obtained with haemolymph; however, wounds treated with the substances taken from S. magellanica had better evolution. Histological analysis revealed that treatment led to tissue proliferation and more effective neovascularisation in less time with both species' fat body extracts compared to treatment with just haemolymph. The results suggest the effectiveness of the substances evaluated and validate them in the animal model being used here as topical agents in treating chronic wounds. © 2015 Jennifher Góngora et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/270253
dc.identifier.issn2314-6745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21646
dc.language.isoengspa
dc.relation.citationTitleJournal of Diabetes Research
dc.relation.citationVolumeVol. 2015
dc.relation.ispartofJournal of Diabetes Research, ISSN: 2314-6745 Vol. 2015, (2015)spa
dc.relation.urihttps://www.hindawi.com/journals/jdr/2015/270253/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectalloxanspa
dc.subjectnitrofuralspa
dc.subjectSarconesiopsis magellanica fat body extractspa
dc.subjectunclassified drugspa
dc.subjectwound healing promoting agentspa
dc.subjectalloxan-induced diabetes mellitusspa
dc.subjectDiabetesspa
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.lembDiabetesspa
dc.subject.lembHeridasspa
dc.titleEvaluating the effect of sarconesiopsis magellanica (Diptera: Calliphoridae) larvae-derived haemolymph and fat body extracts on chronic wounds in diabetic rabbitsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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