Neighboring gene regulation by antisense long Non-Coding RNAs

Villegas Gálvez, Victoria Eugenia; Zaphiropoulos, Peter

doi:https://doi.org/10.3390/ijms16023251

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Neighboring gene regulation by antisense long Non-Coding RNAs

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dc.creator	Villegas Gálvez, Victoria Eugenia
dc.creator	Zaphiropoulos, Peter
dc.creator.google	Villegas, Victoria E.	spa
dc.creator.google	Zaphiropoulos, Peter G.	spa
dc.date.accessioned	2020-04-03T03:37:08Z
dc.date.available	2020-04-03T03:37:08Z
dc.date.created	2015
dc.date.issued	2015
dc.description.abstract	Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm. © 2015 by the authors; licensee MDPI, Basel, Switzerland.	eng
dc.format.mimetype	application/pdf
dc.identifier.doi	https://doi.org/10.3390/ijms16023251
dc.identifier.issn	1661-6596
dc.identifier.uri	https://repository.urosario.edu.co/handle/10336/21464
dc.language.iso	eng	spa
dc.relation.citationEndPage	3266
dc.relation.citationIssue	No. 2
dc.relation.citationStartPage	3251
dc.relation.citationTitle	International Journal of Molecular Sciences
dc.relation.citationVolume	Vol. 16
dc.relation.ispartof	International Journal of Molecular Sciences, ISSN: 1661-6596 Vol. 16, No. 2 (2015) pp. 3251-3266	spa
dc.relation.uri	https://www.mdpi.com/1422-0067/16/2/3251	spa
dc.rights.accesRights	info:eu-repo/semantics/openAccess
dc.rights.acceso	Abierto (Texto Completo)	spa
dc.source.instname	instname:Universidad del Rosario
dc.source.reponame	reponame:Repositorio Institucional EdocUR
dc.subject	regulatory RNA	spa
dc.subject	antisense transcription	spa
dc.subject	long non-coding RNAs	spa
dc.subject	gene regulation	spa
dc.subject.ddc	Evolución & genética	spa
dc.subject.lemb	Fenómenos biológicos	spa
dc.subject.lemb	Ácidos nucleicos	spa
dc.title	Neighboring gene regulation by antisense long Non-Coding RNAs	spa
dc.type	review	eng
dc.type.hasVersion	info:eu-repo/semantics/publishedVersion
dc.type.spa	Revisión	spa