Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
Alba, Martha P.
Patarroyo, Manuel A.
Patarroyo, Manuel E.
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo.
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