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Acceso Abierto
Mechanism of action of Type 2 Sodium-Glucose Cotransporter Inhibitors: Beyond glycaemic control
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Autores
Sandoval, Andrés Felipe Buitrago
Vallejo, Carlos Andrés Sánchez
Fecha
2020
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Elsevier B.V.
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Abstract
Type 2 Sodium-Glucose Cotransporter (SGLT2) Inhibitors exercise their glucose-lowering effect through the inhibition of glucose reabsorption in the kidney. However, the cardiovascular and renal effects, as well as in those of cardiac failure, seem to occur independently from the glucose–lowering effects of these drugs. The principal mechanisms of action that explain their cardiovascular benefits are the hypotensive effect and the decrease in fill pressures, as well as direct effects on the metabolism of the myocardial cell. There is also a reduction in the urine albumin, as well as non-glycaemic effects, and a decrease in adipose tissue, with an increase in haematocrit and urine uric acid. Each one of these novel mechanisms is described in this article. © 2019
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Keywords
Albumin , Sodium glucose cotransporter inhibitor , Uric acid , Adipose tissue , Antidiarrheal activity , Antihypertensive activity , Article , Cardiac muscle cell , Cell metabolism , Drug mechanism , Human , Uric acid urine level , Diabetes , Heart failure , Treatment
