Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis
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Pfaff, Alexander W.
Grigg, Michael E.
Gomez-Marin, Jorge E.
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Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-?), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.
Cytokine , ocular , Cytokinome , Eotaxin , Fibroblast growth factor , Gamma interferon , Gamma interferon inducible protein 10 , Interleukin 10 , Interleukin 13 , Interleukin 15 , Interleukin 17 , Interleukin 4 , Interleukin 5 , Interleukin 9 , Macrophage inflammatory protein 1alpha , Macrophage inflammatory protein 1beta , Monocyte chemotactic protein 1 , Platelet derived growth factor bb , Platelet derived growth factor beta receptor , Rantes , Unclassified drug , Vasculotropin , Cytokine , Signal peptide , Adult , Aged , Antibody production , Aqueous humor , Article , Cataract extraction , Clinical article , Colombian , Controlled study , Disease severity , Ethnicity , Female , Human , Inflammation , Male , Polymerase chain reaction , Priority journal , Protein expression , Recurrent disease , Regulatory t lymphocyte , Serotype , Symptomatology , Th1 cell , Th17 cell , Th2 cell , Toxoplasma gondii , Toxoplasmosis , Uveitis , Very elderly , Case control study , Eye , Metabolism , Prospective study , Toxoplasmosis , Adult , Aged , Aged, 80 and over , Aqueous humor , Case-control studies , Cytokines , Eye , Female , Humans , Intercellular signaling peptides and proteins , Male , Prospective studies , Toxoplasmosis , Colombia , Intraocular cytokines , Th2 , Toxoplasma gondii , Uveitis