Ítem
Solo Metadatos
Toxoplasma gondii: Immunogenicity and protection by P30 peptides in a murine model
Título de la revista
Autores
Siachoque H.
Guzman F.
Burgos J.
Patarroyo M.E.
Gomez Marin J.E.
Resumen
Abstract
Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge. © 2006 Elsevier Inc. All rights reserved.
Palabras clave
Keywords
Cysteinylisoleucyllysylglycylaspartylaspartylalanylglutaminylseryl cysteinylmethionylvalylthreonylvalylthreonylvalylglutaminylalanylarginylalanine , animal , Isoleucyllysylleucylthreonylvalylprolylisoleucylglutamyllysylphenylalanyl prolylvalylthreonylthreonylglutaminylthreonylphenylalanylvalylvalylglycine , Isoleucylprolylglutamylalanylglutamylaspartylseryltryptophanyltryptophanyl threonylglycylaspartylserylalanylserylleucylaspartylthreonylalanylglycine , Leucylarginylcysteinylglycylvalylmethionylalanylserylaspartylprolylprolyl leucylvalylalanylasparaginylglutaminylvalylvalylthreonylcysteine , Lysylalanylvalylarginylarginylalanylvalylthreonylalanylglycylvalyl phenylalanylalanylalanylprolylthreonylleucylmethionylserylphenylalanine , Lysylcysteinylprolyllysylthreonylalanylleucylthreonylglutamylprolylprolyl threonylleucylalanyltyrosylserylprolylasparaginylarginylglutamine , Lysylserylphenylalanyllysylaspartylisoleucylleucylprolyllysylleucyl threonylglutamylasparaginylprolyltryptophanylglutaminylglycylasparaginylalanyl serine , Lysylvalylprolylglutaminylaspartylasparaginylasparaginylglutaminyltyrosyl cysteinylserylglycylthreonylthreonylleucylthreonylglycylcysteinylasparaginyl glutamic acid , Membrane protein , Methionylserylvalylserylleucylhistidylhistidylphenylalanylisoleucyl isoleucylserylserylglycylphenylalanylleucylthreonylserylmethionylphenylalanyl proline , Peptide derivative , Phenylalanylalanylglycylalanylalanylglycylserylalanyllysylserylalanyl alanylglycylthreonylalanylserylhistidylvalylserylisoleucine , Phenylalanylalanylmethionylvalylisoleucylglycylleucylisoleucylglycylseryl isoleucylalanylalanylcysteinylvalylalanine , Prolylaspartyllysyllysylserylthreonylalanylalanylvalylisoleucylleucyl threonylprolylthreonylglutamylasparaginylhistidylphenylalanylthreonylleucine , Protein sag1 , Serylaspartyllysylglycylalanylthreonylleucylthreonylisoleucyllysyllysyl glutamylalanylphenylalanylprolylalanylglutamylseryllysylserine , Serylserylvalylvalylasparaginylasparaginylalanylarginylcysteinylseryl tyrosylglycylalanylaspartylserylthreonylleucylglycylproline , Unclassified drug , Valylisoleucylisoleucylglycylcysteinylthreonylglycylglycylserylprolyl glutamyllysylhistidylhistidylcysteinylthreonylvalyllysylleucylglutamic acid , Valyllysylleucylserylalanylglutamylglycylprolylthreonylthreonylmethionyl threonylleucylvalylcysteinylglycyllysylaspartylglycylvaline , Animal experiment , Animal model , Article , Carboxy terminal sequence , Controlled study , Immunogenicity , Male , Mouse , Nonhuman , Nucleotide sequence , Priority journal , Survival , Toxoplasma gondii , Toxoplasmosis , Vaccination , Amino acid sequence , Animals , Antibodies , Antigens , Antigens , Immunization , Male , Mice , Mice , Molecular sequence data , Peptides , Protozoan proteins , Protozoan vaccines , Toxoplasma , Toxoplasmosis , Murinae , Toxoplasma , Toxoplasma gondii , Murine model , P30 , Peptides , Sag1 , Toxoplasma gondii , Vaccines
