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Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis
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Cardona, Nestor
de-la-Torre, Alejandra
Siachoque, Heber
Patarroyo, Manuel A.
Gomez-Marin, Jorge E.
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2009
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Abstract
In this study, human sera reactivity against nine peptides derived from the Toxoplasma gondii P30 protein was assessed by ELISA in patients with different clinical forms of toxoplasmosis. Same as has been reported in mice, sera from congenital, ocular and chronic asymptomatic toxoplasmosis patients recognized more strongly peptides from the protein's carboxy-terminus, being peptide 2017 (amino acids 301-320) the one most strongly recognized by sera from patients with ocular toxoplasmosis. Serum samples collected from 13 patients without ocular infection, 13 with inactive chorioretinal scars, 6 with active ocular infection and 10 seronegative individuals were then screened for anti-2017 IgG. Peptide 2017 was recognized by all patients' samples but not by sera from T. gondii-seronegative individuals. No statistically significant differences were found between the absorbance levels of groups with and without lesions or with active or inactive ocular lesions, as determined by ANOVA. © 2009 Elsevier Inc. All rights reserved.
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Immunoglobulin G antibody , Protein p30 , Surface , Protozoan , Ocular , Congenital , Article , Carboxy terminal sequence , Chorioretinopathy , Clinical article , Congenital toxoplasmosis , Controlled study , Eye infection , Human , Humoral immunity , Infant , Molecular recognition , Nonhuman , Nucleotide sequence , Parasite immunity , Priority journal , Toxoplasma gondii , Toxoplasmosis , Amino Acid Sequence , Analysis of Variance , Animals , Antigens , Antigens , Chronic Disease , Enzyme-Linked Immunosorbent Assay , Humans , Immune Sera , Immunoglobulin G , Infant , Molecular Sequence Data , Peptides , Protozoan Proteins , Toxoplasma , Toxoplasmosis , Toxoplasmosis , Toxoplasmosis , Mus , Toxoplasma gondii , Human antibodies , Peptides , SAG1 , Toxoplasma gondii
