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Functional hubs in mild cognitive impairment
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Autores
Navas, Adrián
Papo, David
Boccaletti, Stefano
Del-Pozo, F.
Bajo, Ricardo
Maestú, Fernando
Martínez, J. H.
Gil, Pablo
Sendiña-Nadal, Irene
Buldú, Javier M.
Fecha
2015
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World Scientific Publishing Co. Pte Ltd
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Abstract
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.
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Keywords
Brain mapping , Electric network topology , Magnetoencephalography , Alzheimer's disease , Brain networks , Centrality , Mild cognitive impairments , Mild cognitive impairments (MCI) , Random structures , Short-term memory tasks , Synchronization likelihoods , Neurodegenerative diseases , Centrality , Functional brain networks , Hub characterization , Mild cognitive impairment , Synchronization likelihood
