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Silicon, a Possible Link between Environmental Exposure and Autoimmune Diseases: The Case of Rheumatoid Arthritis

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Date
2012-10-18
Author
Speck-Hernandez, Cesar A.
Montoya-Ortiz, Gladis
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Citation
URI
https://doi.org/10.1155/2012/604187
https://repository.urosario.edu.co/handle/10336/25021

Abstract
Silicon is one of the most common chemicals on earth. Several compounds such as silica, asbestos, silicone or, nanoparticles are built from tetrahedral units with silicon as the central atom. Despite these, structural similarities, they have rarely been analyzed as a group. These compounds generate significant biological alterations that include immune hyperactivation, production of the reactive species of oxygen and tissue injury. These pathological processes may trigger autoimmune responses and lead to the development of rheumatoid arthritis. Populations at risk include those that constantly work in industrial process, mining, and agriculture as well as those that undergo silicone implants. Herein a review on the main features of these compounds and how they may induce autoimmune responses is presented.

Keyword

Medical and Health Sciences ; Immunology ;

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http://downloads.hindawi.com/journals/arthritis/2012/604187.pdf...

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