Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein

Matheus Merino, Luisa Marina; Blair, G. Eric

doi:https://doi.org/10.1016/j.bbaexp.2003.08.010

Ítem

Solo Metadatos

Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein

https://repository.urosario.edu.co/handle/10336/25960
https://doi.org/10.1016/j.bbaexp.2003.08.010

Autores

Matheus Merino, Luisa Marina

Blair, G. Eric

Fecha

2003-10-20

Editor

Elsevier

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Métricas alternativas

Abstract

The myelin basic proteins (MBPs) are the major proteins of the myelin membrane. Multiple MBP mRNAs and protein isoforms are generated by alternative RNA splicing. Here we describe the isolation and characterisation of a cDNA clone encoding a 17-kDa MBP isoform from the rat (Rattus norvegicus). The isoform is a 158-amino acid protein consisting of exons 1, 3, 4, 6 and 7 of the MBP gene. RT-PCR analysis of brain mRNA showed that transcripts encoding the 17-kDa isoform were expressed at higher levels early in post-natal development, up to 7 days post-partum.