Ítem
Solo Metadatos
alpha1 and alpha2 domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics.
Título de la revista
Autores
Suárez, C. F.
Cárdenas, P. P.
Llanos-Ballestas, E. J.
Mart?ínez, P.
Obregon, M.
Patarroyo, M. A.
Fecha
2013-05-12
Directores
ISSN de la revista
Título del volumen
Editor
The HLA Award
John Wiley & Sons
John Wiley & Sons
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Resumen
Abstract
Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini’s classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.
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Keywords
Animal models , Aotus , Evolution , MHC class I , PBR , Platyrrhini
