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Myeloid-derived-supressor cells as regulators of th eimmune system
Título de la revista
Autores
Gabilovich, Dmitry
Nagaraj, Srinivas
Fecha
2009-03
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Editor
Nature reviews Immunology
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Resumen
Abstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.
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Keywords
Immunosuppressi , Suppression
