Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

López, Ramsés; Valbuena, John; Rodríguez, Luis E.; Ocampo, Marisol; Vera, Ricardo; Curtidor, Hernando; Puentes, Alvaro; García, Javier; Ramirez, Luis E.; Patarroyo, Manuel E.

doi:https://doi.org/10.1016/j.peptides.2006.02.001

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Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion

https://repository.urosario.edu.co/handle/10336/26738
https://doi.org/10.1016/j.peptides.2006.02.001

Autores

López, Ramsés

Valbuena, John

Rodríguez, Luis E.

Ocampo, Marisol

Vera, Ricardo

Curtidor, Hernando

Puentes, Alvaro

García, Javier

Ramirez, Luis E.

Patarroyo, Manuel E.

Fecha

2006-07

Editor

Elsevier

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Abstract

This work shows that Plasmodium falciparum merozoite surface protein-6 (MSP-6) peptides specifically bind to membrane surface receptor on human erythrocytes. Three high activity binding peptides (HABPs) were found: peptides 31175 (41MYNNDKILSKNEVDTNIESN60) and 31178 (101YDIQATYQFPSTSGGNNVIP120) in the amino terminal region and 31191 (361EIDSTINNLVQEMIHLFSNNY380) at the carboxy terminal. Their binding to erythrocytes was saturable. HABPs 31191 and 31178 recognized 56 and 26 kDa receptors on erythrocyte membrane and inhibited in vitro Plasmodium falciparum merozoite invasion of erythrocytes by between 27% and 46% at 200 ?g ml?1 concentration, suggesting that these MSP-6 protein peptides play a possible role in the invasion process.