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Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases

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Autores
Anaya, Juan-Manuel
Sany, J.
Couret, M.
Combe, B.
Daures JP.

Fecha
1991

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Editor
Europe PMC

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Resumen
Abstract
One hundred and ninety-one patients with severe rheumatoid arthritis (RA) were included in a prospective open longterm study of the safety, efficacy and maintenance of methotrexate (MTX) treatment. The mean duration of MTX treatment was 19 +/- 13.2 (3-58) months; the mean weekly dose of MTX was 10.2 +/- 0.2 mg. Analysis of the 191 patients in an intent-to-treat manner showed a significant improvement of all the clinical variables and a decrease of erythrocyte sedimentation rate with a steroid sparing effect. The probability of continuing MTX therapy for up to 2 years was 65% and for up to 5 years was 46%. Adverse effects of MTX occurred in 37.1% of the patients, but only 15.7% discontinued MTX permanently.
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Keywords
Safety , Efficacy , Maintenance
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