Ítem
Solo Metadatos
Induction and displacement of an helix in the 6725 SERA peptide analogue confers protection against P. falciparum malaria.
Título de la revista
Autores
Alaba, Martha Patricia
Salazar, Luz Mary
Purmova, Jindra
Vanegas, Magnolia
Rodriguez, Raul
Patarroyo, Manuel Elkin
Fecha
2004
Directores
ISSN de la revista
Título del volumen
Editor
Elsevier
Citations
Métricas alternativas
Resumen
Abstract
The protein called serine repeat antigen (SERA) is a Plasmodium falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues. These peptides were studied by 1H NMR to try to correlate their structure with their biological function. These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their three-dimensional (3D) structure, suggesting that such modifications may allow a better fit with immune system molecules.
Palabras clave
Keywords
Peptide , Malaria , SERA , NMR
Citations
