Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

Caicedo Dorado, Alexander; Naulaers, G; Van Huffel; Van Bel, Frank; Lemmers, Petra; Alderliesten, Thomas; Varon, Carolina

doi:https//doi.org 10.1109/EMBC.2014.6944552

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Differences in the cerebral hemodynamics regulation mechanisms of premature infants with intra-ventricular hemorrhage assessed by means of phase rectified signal averaging

https://repository.urosario.edu.co/handle/10336/28429
https//doi.org 10.1109/EMBC.2014.6944552

Autores

Caicedo Dorado, Alexander

Naulaers, G

Van Huffel

Van Bel, Frank

Lemmers, Petra

Alderliesten, Thomas

Varon, Carolina

Fecha

2014-08-26

Editor

Engineering in Medicine and Biology Society

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Abstract

Cerebral hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants, due to the immaturity of their cerebral vascular bed, these mechanisms might be impaired exposing their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring the coupling between some systemic variables, such as Mean arterial blood pressure (MABP) and concentration of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (rScO 2 ) measured by means of Near-infrared Spectroscopy. We hypothesized that the coupled dynamics between systemic variables and rScO 2 is different in premature infants that suffered from brain damage than in those with a favorable clinical outcome. Therefore, we explore the use of phase rectified signal averaging (PRSA) and bi-variate PRSA (BPRSA) in order to identify these differences. We found that the coupled dynamics between changes in MABP and cerebral oxygenation was different in premature infants that suffered III-IV grade intra-ventricular haemorrhage (IVH), when compared to control subjects.