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Evidence of association between SNAP25 gene and attention deficit hyperactivity disorder in a Latin American sample

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dc.creatorGálvez, Jubby M.spa
dc.creatorGarzon-Forero, Diego Aspa
dc.creatorFonseca Mendoza, Dora Janethspa
dc.creatorMateus, Heidi E.spa
dc.creatorTalero Gutiérrez, Claudia
dc.creatorVélez van Meerbeke, Alberto Franciscospa
dc.date.accessioned2020-05-26T00:05:16Z
dc.date.available2020-05-26T00:05:16Z
dc.date.created2014spa
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is one of the most highly heritable behavioral disorders in childhood, with heritability estimates between 60 and 90 %. Family, twin and adoption studies have indicated a strong genetic component in the susceptibility to ADHD. The synaptosomal-associated protein of molecular weight 25 kDa (SNAP25) is a plasma membrane protein known to be involved in synaptic and neural plasticity. Animal model studies have shown that SNAP25 gene is responsible for hyperkinetic behavior in the coloboma mouse. In recent studies, several authors reported an association between SNAP25 and ADHD. In this study, we used a case-control approach to analyze the possible association of two polymorphisms of SNAP25 for possible association with ADHD in a sample of 73 cases and 152 controls in a Colombian children population. Polymorphisms are located in 3? untranslated region of SNAP25, positions T1065G and T1069C. We found a significant association with the GT haplotype (rs3746554{pipe}rs1051312) of SNAP25 (p = 0.001). Evidence of association was also found for the G/G genotype of rs3746554 (p = 0.002) and C/C genotype of rs1051312 (p = 0.009). This is the first study in a Latin American population. Similar to other studies, we found evidence of the association of SNAP25 and ADHD. © 2013 Springer-Verlag Wien.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12402-013-0123-9
dc.identifier.issn18666647
dc.identifier.issn18666116
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23774
dc.language.isoengspa
dc.relation.citationEndPage23
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage19
dc.relation.citationTitleADHD Attention Deficit and Hyperactivity Disorders
dc.relation.citationVolumeVol. 6
dc.relation.ispartofADHD Attention Deficit and Hyperactivity Disorders, ISSN:18666647, 18666116, Vol.6, No.1 (2014); pp. 19-23spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896839235&doi=10.1007%2fs12402-013-0123-9&partnerID=40&md5=af6a5cf16b39ccbc48da5ae4c8963557spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordSynaptosomal associated protein 25spa
dc.subject.keywordsingle nucleotideeng
dc.subject.keyword3' untranslated regionspa
dc.subject.keywordArticlespa
dc.subject.keywordAttention deficit disorderspa
dc.subject.keywordChildspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein polymorphismspa
dc.subject.keywordQuestionnairespa
dc.subject.keywordRestriction fragment length polymorphismspa
dc.subject.keywordSchool childspa
dc.subject.keywordScoring systemspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordAttention deficit disorder with hyperactivityspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordChildspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic association studiesspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSynaptosomal-associated protein 25spa
dc.subject.keyword3?utrspa
dc.subject.keywordAdhdspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordPolymorphismspa
dc.subject.keywordRs1051312spa
dc.subject.keywordRs3746554spa
dc.subject.keywordSnap25spa
dc.titleEvidence of association between SNAP25 gene and attention deficit hyperactivity disorder in a Latin American samplespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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