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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components

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dc.creatorBermudez, Adriana
dc.creatorAlba, Martha P.
dc.creatorVanegas, Magnolia
dc.creatorPatarroyo, Manuel A.
dc.creatorPatarroyo, Manuel E.
dc.creator.googleBermudez, Adrianaspa
dc.creator.googleAlba, Martha P.
dc.creator.googleVanegas, Magnolia
dc.creator.googlePatarroyo, Manuel A.
dc.creator.googlePatarroyo, Manuel E.
dc.date.accessioned2019-10-01T13:58:59Z
dc.date.available2019-10-01T13:58:59Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractThe 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.3389/fchem.2018.00106
dc.identifier.issn2296-2646
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20372
dc.language.isoengspa
dc.relation.citationTitleFrontiers in Chemistry
dc.relation.citationVolumeVol. 6
dc.relation.ispartofFrontiers in Chemistry, ISSN:2296-2646, Vol. 6 (2018)spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fchem.2018.00106/fullspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationAdzhubei, A.A., Sternberg, M.J., Makarov, A.A., Polyproline-II helix in proteins: structure and function (2013) J. Mol. Biol, 425, pp. 2100-2132spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectVacuna contra la malariaspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordβ-turnsspa
dc.subject.keywordStructure-functionspa
dc.subject.keywordIMPIPSspa
dc.subject.keywordLLPIspa
dc.subject.keywordPPIILspa
dc.subject.keywordMalaria vaccinespa
dc.subject.lembMalariaspa
dc.subject.lembPlasmodiumspa
dc.titleSpecific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Componentsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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