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Etiopathogenesis of autoimmune hepatitis

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dc.creatorFloreani A.spa
dc.creatorRestrepo-Jiménez P.spa
dc.creatorSecchi M.F.spa
dc.creatorDe Martin S.spa
dc.creatorLeung P.S.C.spa
dc.creatorKrawitt E.spa
dc.creatorBowlus C.L.spa
dc.creatorGershwin M.E.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:55Z
dc.date.available2020-05-25T23:55:55Z
dc.date.created2018spa
dc.description.abstractAutoimmune hepatitis is a chronic inflammatory liver disease characterized by hypergammaglobulinemia, the presence of autoantibodies, and inflammation within the liver, including lymphocytic infiltrates and interface hepatitis. Autoimmune hepatitis shows a female predominance and can present at any age and in any ethnicity. The disease is thought to be a consequence of a break of immune tolerance leading to an autoimmune process that induces liver injury. The self-attack is triggered by T-helper cell-mediated liver autoantigen recognition and B-cell production of autoantibodies, and is sustained by impaired regulatory T cells number and function. Superimposed on a genetic predisposition, infections and environmental factors have been studied as triggering factors for the disease. Allelic variants in the HLA locus have been associated with susceptibility; associations with single nucleotide polymorphisms within non-HLA genes have also been assessed. Several factors have been described as triggers of autoimmune responses in predisposed individuals, including infections, alcohol, vitamin D deficiency, and an altered composition of the intestinal microbiome. Importantly, drugs and herbal agents may trigger classical autoimmune hepatitis, or may induce a liver disease with autoimmune features. Interactions between female hormones and genetic factors have been hypothesized to play a role in autoimmunity, although the exact role for these factors has not been fully established. Herein we present a review of the etiology of autoimmune hepatitis including de novo autoimmune hepatitis post-liver transplantation as well as animal models for its study. © 2018eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2018.10.020
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22262
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage143
dc.relation.citationStartPage133
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 95
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.95,(2018); pp. 133-143spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059313399&doi=10.1016%2fj.jaut.2018.10.020&partnerID=40&md5=0e3f4384674afe4db0c2e4e68dbd426fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordautoimmuneeng
dc.subject.keywordregulatoryeng
dc.subject.keywordhelper-inducereng
dc.subject.keywordbiliaryeng
dc.subject.keywordAutoantigenspa
dc.subject.keywordCytochrome p450 1a2spa
dc.subject.keywordCytochrome p450 2a6spa
dc.subject.keywordDrugspa
dc.subject.keywordHerbaceous agentspa
dc.subject.keywordSex hormonespa
dc.subject.keywordHla antigenspa
dc.subject.keywordAlcohol consumptionspa
dc.subject.keywordAlcohol metabolismspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordB lymphocytespa
dc.subject.keywordBacterial infectionspa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordHelper cellspa
dc.subject.keywordHeredityspa
dc.subject.keywordHistocompatibility genespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunizationspa
dc.subject.keywordImmunological tolerancespa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordIntestine floraspa
dc.subject.keywordKnockout mousespa
dc.subject.keywordLiver homogenatespa
dc.subject.keywordLiver injuryspa
dc.subject.keywordLiver transplantationspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordMouse modelspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitosisspa
dc.subject.keywordPostoperative complicationspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRegulatory t lymphocytespa
dc.subject.keywordReviewspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordToxic hepatitisspa
dc.subject.keywordTransgenic mousespa
dc.subject.keywordVirus infectionspa
dc.subject.keywordVitamin d deficiencyspa
dc.subject.keywordAdverse eventspa
dc.subject.keywordAlcoholismspa
dc.subject.keywordAnimalspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordBiliary cirrhosisspa
dc.subject.keywordBiosynthesisspa
dc.subject.keywordCommunicable diseasespa
dc.subject.keywordComplicationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotype environment interactionspa
dc.subject.keywordImmunologyspa
dc.subject.keywordLiverspa
dc.subject.keywordPathologyspa
dc.subject.keywordSex factorspa
dc.subject.keywordVitamin d deficiencyspa
dc.subject.keywordAlcoholismspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordB-lymphocytesspa
dc.subject.keywordCommunicable diseasesspa
dc.subject.keywordGene-environment interactionspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHepatitiseng
dc.subject.keywordHla antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordLiverspa
dc.subject.keywordLiver cirrhosiseng
dc.subject.keywordLiver transplantationspa
dc.subject.keywordSex factorsspa
dc.subject.keywordT-lymphocyteseng
dc.subject.keywordT-lymphocyteseng
dc.subject.keywordVitamin d deficiencyspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordGenome-wide association studiesspa
dc.subject.keywordHormonesspa
dc.subject.keywordMicrobiomespa
dc.subject.keywordPrimary biliary cholangitisspa
dc.subject.keywordPrimary sclerosing cholangitisspa
dc.titleEtiopathogenesis of autoimmune hepatitisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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