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Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier

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dc.creatorPinzón-Daza M.L.spa
dc.creatorCampia I.spa
dc.creatorKopecka J.spa
dc.creatorGarzón R.spa
dc.creatorGhigo D.spa
dc.creatorRiganti C.spa
dc.date.accessioned2020-05-26T00:05:32Z
dc.date.available2020-05-26T00:05:32Z
dc.date.created2013spa
dc.description.abstractThe blood-brain barrier (BBB), the unusual microvascular endothelial interface between the central nervous system (CNS) and the circulatory system, is a major hindrance to drug delivery in the brain parenchyma. Besides the absence of fenestrations and the abundance of tight junctions, ATP-binding cassette (ABC) transporters critically reduce drug entry within the CNS, as they carry many drugs back into the bloodstream. Nanoparticle-and liposome-carried drugs, because of their increased cellular uptake and reduced efflux through ABC transporters, have been developed in recent times to circumvent the low drug permeability of the BBB. This review discusses the role of ABC transporters in controlling drug penetration into the brain parenchyma, the rationale for using nanoparticle-and liposome-based strategies to increase drug delivery across the BBB and new therapeutic strategies for using nanoparticle-and liposome-carried drugs in different conditions, ranging from CNS tumors and neurodegenerative diseases to viral infections and epilepsy. © 2013 Bentham Science Publishers.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1389200211314060001
dc.identifier.issn13892002
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23802
dc.language.isoengspa
dc.relation.citationEndPage640
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage625
dc.relation.citationTitleCurrent Drug Metabolism
dc.relation.citationVolumeVol. 14
dc.relation.ispartofCurrent Drug Metabolism, ISSN:13892002, Vol.14, No.6 (2013); pp. 625-640spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84882425413&doi=10.2174%2f1389200211314060001&partnerID=40&md5=d234a99dd61a9157d6259fe7be0eded9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDactinomycinspa
dc.subject.keywordDasatinibspa
dc.subject.keywordDaunorubicinspa
dc.subject.keywordDocetaxelspa
dc.subject.keywordDoxorubicinspa
dc.subject.keywordEpirubicinspa
dc.subject.keywordErlotinibspa
dc.subject.keywordEtoposidespa
dc.subject.keywordGefitinibspa
dc.subject.keywordIndinavirspa
dc.subject.keywordIrinotecanspa
dc.subject.keywordKetoconazolespa
dc.subject.keywordLamivudinespa
dc.subject.keywordLapatinibspa
dc.subject.keywordLiposomespa
dc.subject.keywordMethotrexatespa
dc.subject.keywordMitoxantronespa
dc.subject.keywordNanoparticlespa
dc.subject.keywordNelfinavirspa
dc.subject.keywordPaclitaxelspa
dc.subject.keywordProbenecidspa
dc.subject.keywordSaquinavirspa
dc.subject.keywordSorafenibspa
dc.subject.keywordTeniposidespa
dc.subject.keywordTopotecanspa
dc.subject.keywordUnindexed drugspa
dc.subject.keywordVerlukastspa
dc.subject.keywordVinblastinespa
dc.subject.keywordVincristinespa
dc.subject.keywordZidovudinespa
dc.subject.keywordBlood brain barrierspa
dc.subject.keywordControlled drug releasespa
dc.subject.keywordDegenerative diseasespa
dc.subject.keywordDrug coatingspa
dc.subject.keywordDrug degradationspa
dc.subject.keywordDrug delivery systemspa
dc.subject.keywordDrug distributionspa
dc.subject.keywordDrug mechanismspa
dc.subject.keywordDrug penetrationspa
dc.subject.keywordDrug synthesisspa
dc.subject.keywordDrug targetingspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordGene therapyspa
dc.subject.keywordGlioblastomaspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordHydrophilicityspa
dc.subject.keywordHydrophobicityspa
dc.subject.keywordIn vivo studyspa
dc.subject.keywordLipophilicityspa
dc.subject.keywordNanoencapsulationspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParenchymaspa
dc.subject.keywordPhysical chemistryspa
dc.subject.keywordReviewspa
dc.subject.keywordSurface propertyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAtp-binding cassette transportersspa
dc.subject.keywordBiological transportspa
dc.subject.keywordBlood-brain barrierspa
dc.subject.keywordHumansspa
dc.subject.keywordLiposomesspa
dc.subject.keywordNanoparticlesspa
dc.subject.keywordPharmaceutical preparationsspa
dc.subject.keywordAtp-binding cassette transportersspa
dc.subject.keywordBlood-brain barrierspa
dc.subject.keywordCentral nervous systemspa
dc.subject.keywordDrug deliveryspa
dc.subject.keywordLiposomesspa
dc.subject.keywordNanoparticlesspa
dc.titleNanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrierspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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