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[177Lu – DOTA – Tyr3] – OCTREOTATE para el tratamiento de tumores neuroendocrinos gastroenteropancreáticos. Revisión sistemática de la literatura.

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dc.contributor.advisorArévalo Leal, José Sinay
dc.contributor.advisorMorón Duarte, Lina Sofía
dc.creatorHerrera Malo, Yariela Edith
dc.creatorArévalo Leal, José Sinay
dc.creatorMejía-López, Arturo
dc.creator.degreeEspecialista en Medicina Nuclear
dc.date.accessioned2014-01-16T19:21:39Z
dc.date.available2014-01-16T19:21:39Z
dc.date.created2013-11-22
dc.date.issued2013
dc.descriptionIntroducción: los tumores neuroendocrinos gastroenteropancreáticos se diagnostican en estadio avanzado en 60 - 80% de los pacientes y las opciones terapéuticas son limitadas. Se realizó una revisión sobre el beneficio clínico del tratamiento con [177Lu - DOTA - Tyr3] - Octreotate en pacientes con enfermedad metastásica o inoperable. Objetivos: evaluar la eficacia, impacto en calidad de vida y toxicidad de la terapia con 177Lu DOTATE en pacientes con tumores neuroendocrinos gastroenteropancreáticos avanzados. Materiales y Métodos: se condujo una revisión sistemática de la literatura mediante la búsqueda de estudios clínicos prospectivos y retrospectivos en bases electrónicas (MEDLINE, EMBASE, LILACS, SCIELO, OVID y la Biblioteca Cochrane) de cualquier idioma, año y estado de publicación. Se incluyeron 5 estudios, por la heterogeneidad existente entre los estudios no se realizó un metaanálisis. Resultados: la respuesta tumoral global fue del 45 - 57%, la enfermedad permaneció estable en 27% - 38% y progresó en 6% - 21% de casos en las series incluidas. El tiempo libre de progresión osciló entre 31 - 40 meses y la sobrevida global de 31– 51 meses. Se observó toxicidad hematológica grado 3-4 hasta en 9.5% de pacientes. Hubo mejoría significativa en la calidad de vida de pacientes tratados con 177LuDOTATATE. Conclusiones: la terapia con 177Lu- DOTATATE ofrece un beneficio clínico a los pacientes con tumores neuroendocrinos bien diferenciados avanzados por su impacto positivo en calidad de vida, control de síntomas, ralentiza la progresión tumoral y su toxicidad es baja.spa
dc.description.abstractGastroenteropancreatic neuroendocrine tumors are diagnosed in advanced state in approximately 60 – 80% of patients, their treatment options are limited. We reviewed the clinical benefit of radionuclide therapy with 177Lu – DOTA – Tyr3] – Octreotate in patients with advanced or inoperable disease. Objective: To assess the efficacy, impact on quality of life and side effects of therapy with 177Lu DOTATE in patients with advanced gastroenteropancreatic neuroendocrine tumors. Materials and Methods: We conducted a systematic review using a peer – reviewed search for clinical prospective and retrospective trials. This search was done in electronic databases (MEDLINE, EMBASE, LILACS, SCIELO, OVID and the Cochrane Library) without language, year or publication status limitations. We included 5 studies; because they were heterogeneous no meta analysis was done. Results: Overall tumor response was seen in 45- 57% of cases, stable disease in 27-38% and progression in 6-21% of cases included in the studies. Time to progression was 31 - 40 months and overall survival 31 – 51 months. Hematologic toxicity grade 3-4 presented in up to 9.5% of patients. Treatment had a significant positive impact in quality of life. Conclusions: Therapy with 177Lu- DOTATATE offers a clinical benefit to patients with advanced gastroenteropancreatic neuroendocrine tumors by improving quality of life, controlling symptoms and limiting progression of disease. The toxicity of the drug is low.eng
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.48713/10336_4835
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/4835
dc.language.isospa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Medicina Nuclearspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject177Lu- DOTATATEspa
dc.subject177Lu-octreotatespa
dc.subjectcarcinoma neuroendocrinospa
dc.subjectgastroenteropancreatic neuroendocrine tumorspa
dc.subjectreceptores de somatostatinaspa
dc.subject.keyword177Lu- DOTATATEeng
dc.subject.keyword177Lu-octreotateeng
dc.subject.keywordgastroenteropancreatic neuroendocrine tumoreng
dc.subject.lembCarcinoma neuroendocrinospa
dc.subject.lembMedicina nuclear::Investigacionesspa
dc.subject.lembNeoplasias pancreáticasspa
dc.subject.lembOctreótido::Utilizaciónspa
dc.subject.lembTumores neuroendocrinos::Diagnósticospa
dc.subject.lembTumores neuroendocrinosspa
dc.title[177Lu – DOTA – Tyr3] – OCTREOTATE para el tratamiento de tumores neuroendocrinos gastroenteropancreáticos. Revisión sistemática de la literatura.spa
dc.typemasterThesiseng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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