Ítem
Solo Metadatos

FRI0513 Does non - erosive rheumatoid arthritis exist ?

Mostrar el registro sencillo de la publicación
dc.creatorAmaya-Amaya, J.spa
dc.creatorCalvo-Páramo, E.spa
dc.creatorCalderon-Páez, A.spa
dc.creatorTorralvo-Morato, G.spa
dc.creatorCalixto, O. J.spa
dc.creatorMantilla, R. D.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorRojas-Villarraga, A.spa
dc.date.accessioned2020-08-06T16:24:08Z
dc.date.available2020-08-06T16:24:08Z
dc.date.created2013-06spa
dc.description.abstractBackground Erosions are the hallmark of rheumatoid arthritis (RA). Although most of erosions may occur within 2 years of onset of the disease, their progression does not correlate with the duration of RA. Moreover, information about non-erosive RA is ambiguous. Objectives To evaluate the prevalence and characteristics of non-erosive RA. Methods Since no agreement about the time-lag interval for erosions appearance in RA exists, and there is no universally accepted definition about it, a zero score in hands and feet X-ray at 5 years of RA duration (by SvHD) was arbitrary considered as cut-off. Therefore, patients meeting these criteria were searched in a large cohort of RA patients (ACR, 1987). Metacarpophalangeal and metatarsophalangeal joints as well as wrist ultrasound (US) imaging (by OMERACT), and computed tomography (CT) were performed to confirm non-erosive RA. Spearman correlation coefficient, kappa analysis and Kendall´s W test were used to analyze data. Results Out of a total of 800 RA patients, 38 met inclusion criteria (4.75%). Most of them were women (76.3%). The median (IQR) of the age and duration of the disease were 52 (13) and 10 (8) years, respectively. Rheumatoid factor (RF) and anti-CCP antibodies were positive in 86.8% and 55.3%, respectively. Non-erosive RA was confirmed by the three methods in only 7 patients. There was no concordance between the three methods. For this sample, the sensitivity and specificity were 70% and 52% for US, and 58% and 57% for CT, respectively. Non-erosive RA was positively although weakly correlated with improved functional class according to the HAQ (r=0.32, p=0.045) and ANA positivity (r=0.43, p=0.030), and negatively correlated with activity of the disease (by RAPID3, r= -0.32, p=0.05), the use of biological therapy (r= -0.31, p=0.05) and RF (r= -0.36, p=0.042). Conclusions Non-erosive RA is rare (0.87%). A good functional class, ANA positivity, RAPID3 score, the use of biological therapy and RF influence the absence of erosions in long-standing RA (i.e., 5 years). Since there is a high variability and a lack of concordance exists among the imagining techniques, a consensus and unified definition about non-erosive RA are warranted.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/annrheumdis-2013-eular.1640
dc.identifier.issnISSN: 0959-8138
dc.identifier.issnEISSN: 1756-1833
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26480
dc.language.isoengspa
dc.publisherBMJ Publishing Groupspa
dc.relation.citationIssueNo. Suppl 3
dc.relation.citationStartPagea548
dc.relation.citationTitleAnnals of the Rheumatic Diseases
dc.relation.citationVolumeVol. 72
dc.relation.ispartofAnnals of the Rheumatic Diseases, ISSN:0959-8138 ; EISSN:1756-1833, Vol.72, No.Suppl 3 (2013-06); pp.a548spa
dc.relation.urihttps://ard.bmj.com/content/72/Suppl_3/A548.2spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceAnnals of the Rheumatic Diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMedical and Health Sciencesspa
dc.subject.keywordClinical Sciencesspa
dc.titleFRI0513 Does non - erosive rheumatoid arthritis exist ?spa
dc.title.TranslatedTitleFRI0513 ¿Existe artritis reumatoide no erosiva?spa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
Archivos
Colecciones
Conferencia y eventos externos