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Modulation of insulin-like growth factors following exercise in breast cancer: A meta-analysis of randomized controlled trials

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dc.creatorMeneses-Echavez, Jose Fspa
dc.creatorRamírez-Vélez, Robinson
dc.creatorCorrea Bautista, Jorge Enriquespa
dc.date.accessioned2020-08-06T16:24:07Z
dc.date.available2020-08-06T16:24:07Z
dc.date.created2015-05-20spa
dc.description.abstractBackground: Insulin resistance,Insulin-like growth factor 1 (IGF-1), IGF-2 and IGF binding protein-3 (IGFBP-3) are associated with breast cancer risk, cell growing, apoptosis and other tumoral mechanisms. This study aimed to determine the changes on IGF system following exercise in women with breast cancer. Methods: PRISMA statement and the Cochrane Handbook were followed. We searched MEDLINE, Ovid, EMBASE and Cochrane Central Registers to identify randomized controlled trials published between 1990 and October 2014. Primary outcomes measures were: Insulin resistance,IGF1, IGF-2 and IGFBP-3, whilst waist circumference was evaluated as a measure of body composition. For pooled analysis, mean difference (MD) (p < 0.05 with 95% Confidence interval). Results: Seven studies (n = 321) were included. There was high quality and a low risk of bias. Pooled analyses demonstrated that exercise training resulted in significant changes on IGF-I (MD = -12.9, 95%CI -16.73 to -9.14), IGF-II (MD = -43.4, 95%CI -58.5 to -28.3), IGFBP-3 (MD = -0.61, 95%CI -0.69 to -0.53) and waist circumference (MD = -1.13, 95%CI -2.20 to -0.05). Conversely, non-significant differences were found for Insulin Resistance (MD = 0.64, 95%CI -0.01 to 1.29), Insulin (MD = 0.04, 95%CI -0.24 to 0.34) and Glucose (MD = 0.22, 95%CI -0.32 to 0.78). Reporting bias was not observed. Conclusions: The serum levels of insulin like growth factors (IGF1-IGF2) and IGFBP3 were positively modulated by exercise training in breast cancer survivors, enhancing the physiological basis of exercise in regulating cellular proliferation and other tumoral mechanisms in breast cancer.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1200/jco.2015.33.15_suppl.e22012
dc.identifier.issnISSN: 0732-183X
dc.identifier.issnEISSN: 1527-7755
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26475
dc.language.isoengspa
dc.publisherAmerican Society of Clinical Oncologyspa
dc.relation.citationEndPagee22012
dc.relation.citationIssueNo. 15_suppl
dc.relation.citationStartPagee22012
dc.relation.citationTitleJournal of Clinical Oncology
dc.relation.citationVolumeVol. 33
dc.relation.ispartofJournal of Clinical Oncology, ISSN: 0732-183X ; EISSN:1527-7755, Vol.33, No.15_suppl (2015); pp.e22012-e22012spa
dc.relation.urihttps://ascopubs.org/doi/10.1200/jco.2015.33.15_suppl.e22012spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceJournal of Clinical Oncologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordInsulinspa
dc.subject.keywordBreast cancerspa
dc.subject.keywordClinical Sciencesspa
dc.subject.keywordOncology and Carcinogenesisspa
dc.titleModulation of insulin-like growth factors following exercise in breast cancer: A meta-analysis of randomized controlled trialsspa
dc.title.TranslatedTitleModulación de factores de crecimiento similares a la insulina después del ejercicio en el cáncer de mama: un metanálisis de ensayos controlados aleatoriosspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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