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Ablación percutánea por radiofrecuencia y microondas de lesiones focales hepáticas, experiencia en un hospital de alta complejidad.

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dc.contributor.advisorPérez Hidalgo, Juan Manuel
dc.contributor.advisorCárdenas-Roldán, Jorge
dc.creatorAldana Silva, Carolina
dc.creatorPiñeros Nieto, Diego Alejandro
dc.creator.degreeEspecialista en Radiologíaspa
dc.creator.degreetypeFull timespa
dc.date.accessioned2020-08-10T00:03:07Z
dc.date.available2020-08-10T00:03:07Z
dc.date.created2020-07-27
dc.descriptionIntroducción: El carcinoma hepatocelular (CHC) tiene alta prevalencia y tasa de mortalidad a nivel mundial. El manejo de CHC pequeños con técnicas locorregionales guiadas por imágenes en pacientes candidatos a trasplante hepático, funciona de manera efectiva en la disminución del tamaño de las lesiones, con bajas tasas de complicaciones. Objetivo: Describir la experiencia en ablación por radiofrecuencia (ARF) y microondas (AMO) de lesiones focales hepáticas (LFH) probable o definitivamente sugestivas de CHC en una institución con centro de trasplante de cuarto nivel. Materiales y métodos: De 2013 a 2019, 97 pacientes con CHC se manejaron con ARF/AMO en la Fundación Cardioinfantil, para un total de 158 lesiones. Se revisaron de manera retrospectiva los datos clínicos, número y tamaño de las lesiones, respuesta y complicaciones. Se realizó un análisis univariado y bivariado en los programas SPSS y R. Resultados: 68 pacientes cumplieron los criterios de inclusión, 64,7% eran hombres, con edad media de 68,2 años. La causa de cirrosis (58,8% Child A) más prevalente fue la alcohólica (23,5%). Todas las lesiones clasificadas LIRADS (LR) 4 (probablemente CHC) o LR 5 (definitivamente CHC), con tamaño promedio de 2,4 cm. Se obtuvo respuesta completa en el 76,5% de las lesiones manejadas. Conclusión: La ablación es una técnica de tratamiento locorregional que produce calor y generar destrucción tumoral mediante necrosis por licuefacción. Esta es una técnica segura, con baja tasa de complicaciones y funciona como terapia puente en pacientes enlistados a trasplante.spa
dc.description.abstractIntroduction: Hepatocellular carcinoma (HCC) has high worldwide prevalence and mortality rate. Treatment of small HCC with image-guided locoregional techniques in patients candidates for liver transplantation, works effectively in decreasing lesions size, with low complication rates. Objective: To describe the experience in radiofrequency ablation (RFA) and microwave ablation (MWA) of hepatic focal lesions probably or definitely HCC in the transplant center of a fourth level hospital. Materials and methods: From 2013 to 2019, 97 patients were treated with RFA/MWA at Fundación Cardioinfantil, for a total of 158 ablation procedures. Clinical data, number and size of lesions, response and complications were retrospectively reviewed. Univariate and bivariate analysis was performed using SPSS and R. Results: 68 patients were analyzed, 64,7% were men, with mean age of 68,2 years. Alcohol (23,5%) was the most related cause of cirrhosis (58,8% Child A). Most lesions LIRADS (LR) 4 (probably HCC) or LR 5 (definitely HCC), had an average size of 2,4 cm. Complete response was observed in 76,5% lesions. Conclusion: Ablation is a locoregional treatment technique that produce heat and inducing tumor destruction by liquefaction necrosis. This is a safe technique, with a low complications rate and works as a bridge therapy in patients enrolled for transplant.spa
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dc.identifier.doihttps://doi.org/10.48713/10336_26518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26518
dc.language.isospaspa
dc.publisherUniversidad del Rosariospa
dc.publisher.departmentFacultad de Medicinaspa
dc.publisher.programEspecialización en Radiologíaspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
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dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectCarcinoma hepatocelularspa
dc.subjectTécnicas de ablaciónspa
dc.subjectImagen por resonancia magnéticaspa
dc.subject.ddcGinecología & otras especialidades médicasspa
dc.subject.ddcFarmacología & terapéuticaspa
dc.subject.keywordHepatocellular carcinomaspa
dc.subject.keywordAblation techniquesspa
dc.subject.keywordMagnetic resonance imagingspa
dc.titleAblación percutánea por radiofrecuencia y microondas de lesiones focales hepáticas, experiencia en un hospital de alta complejidad.spa
dc.title.TranslatedTitlePercutaneous radiofrequency and microwave ablation of focal hepatic lesions, experience in a high complexity hospital.eng
dc.typemasterThesiseng
dc.type.documentDescriptivo observacional retrospectivospa
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaTrabajo de gradospa
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