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Antidepressants in painful diabetic neuropathy

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dc.creatorGutierrez Alvarez, A.M.spa
dc.creatorMoreno, C.B.spa
dc.date.accessioned2020-08-06T16:24:09Z
dc.date.available2020-08-06T16:24:09Z
dc.date.created2008-08spa
dc.description.abstractBackground: The incidence of diabetic neuropathy increases withthe duration of diabetes and the degree of hyperglycaemia. Pain isone of the most common and incapacitating symptoms of diabeticneuropathy and its pharmacological control is complex. The effec-tiveness of antidepressive agents has been described in differenttypes of neuropathic pain, but their effectiveness when used as anal-gesics in painful diabetic neuropathy still remains controversial.The objective was to review the possible role of antidepressiveagents for the treatment of pain in diabetic peripheral neuropathy.Thus, this work has consisted of meta-analysis for determiningwhich antidepressive agent had the best analgesic potential for man-aging pain in patients suffering from painful diabetic neuropathy.Methods: The search covered the Cochrane, MEDLINE,EMBASE and LILACS databases, between January 2000 andAugust 2007. The following information was obtained from eacharticle: criteria for diagnosing diabetic neuropathy, patients’ aver-age age, antidepressant drug received and dose, sample size, dura-tion of the disease and treatment follow-up, outcome measure-ment, evaluation of pain and rescue medication.Results: A combined RR: 1.67 (95% CI 1.38–2.02) was obtained;this result indicated that the antidepressive agents studied wereeffective for controlling pain in diabetic neuropathy. The corre-sponding NNT for Duloxetine was established, according to ourinterests; NNT = 6 (95% CI 5–8) for achieving greater than 50%analgesia in patients suffering from painful diabetic neuropathy.Conclusion: Antidepressive agents are frequently employed in thespecific case of diabetic neuropathy; the combined result of thismeta-analysis has demonstrated their analgesic benefit.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1468-1331.2008.02285.x
dc.identifier.issnISSN: 1351-5101
dc.identifier.issnEISSN: 1468-1331
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26492
dc.language.isoengspa
dc.publisherWiley Online Libraryspa
dc.relation.citationIssueNo. s3
dc.relation.citationStartPage138
dc.relation.citationTitleEuropean Journal of Neurology;The 12th Congress of the EFNS, Madrid, Spain, 2008
dc.relation.citationVolumeVol. 15
dc.relation.ispartofEuropean Journal of Neurology, ISSN: 1351-5101 ; EISSN: 1468-1331, Vol.15, No.s3 (2008-08); pp.138spa
dc.relation.ispartofCongress of the EFNS, No.12 (2008); P1505spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1468-1331.2008.02285.xspa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceEuropean Journal of Neurologyspa
dc.sourceThe 12th Congress of the EFNS, Madrid, Spain, 2008spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordNeurosciencesspa
dc.subject.keywordMedical and Health Sciencesspa
dc.subject.keywordClinical Sciencesspa
dc.titleAntidepressants in painful diabetic neuropathyspa
dc.title.TranslatedTitleAntidepresivos en la neuropatía diabética dolorosa.spa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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