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Genetic and epigenetic effects in a population of underground miners with coal workers Pneumoconiosis

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dc.creatorNarváez, DMspa
dc.creatorVarona Uribe, Marcela Eugenia
dc.creatorPalma, RMspa
dc.creatorBriceño Ayala, Leonardospa
dc.creatorHernández-Vargas, Hspa
dc.creatorGroot, Hspa
dc.date.accessioned2020-09-11T21:06:16Z
dc.date.available2020-09-11T21:06:16Z
dc.date.created2019-09-19spa
dc.description.abstractCoal Workers Pneumoconiosis (CWP) is a respiratory occupational disease caused by chronic exposure to breathable mine dust which is characterized by an inflammatory reaction and a subsequent progressive massive fibrosis. The disease is irreversible and incurable; therefore, early diagnosis or prediction may become useful to control CWP. Oxidative stress is known to play an important rolein pathogenesis.Oxidative DNA damageis repaired by the Base Excision Repair (BER) pathway; therefore,genetic variations in BER pathway enzymes may confer differential risk in CWP. On the other hand, as has been shown for other environmental pollutants DNA methylation may represent an interface between exposure and disease. Biomarkers of exposure, effect and susceptibility were assessed in order to evaluate oxidative stress and methylation changes associated with the disease and the influence ofOGG1and XRCC1polymorphisms in CWP development. A group of 474 underground coal miners were selected to participate in this cross-sectional study. This population was subdivided into two groups of healthy and CWP miners. We show that underground miners who develop pneumoconiosis have a higher level of the oxidative stress marker 8-OHdG in white blood cells, and that this oxidative DNA damage was associated withXRCC1194Trp allele. In addition, leukocytes from CWP cases are differentially methylated at two immune-related loci when compared with control miners, as assessed by bisulfite pyrosequencing. Information regarding genetic, epigenetic and exposure conditions will contribute to the better understanding of disease aetiology in a population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1002/em.22328
dc.identifier.issnEISSN: 1098-2280
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/29857
dc.language.isoeng
dc.publisherEnvironmental Mutagenesis and Genomics Societyspa
dc.relation.citationIssueSupl. 1
dc.relation.citationStartPage53
dc.relation.citationTitleEnvironmental Mutagenesis and Genomics Society 50th Annual Meeting
dc.relation.citationVolumeVol. 60
dc.relation.ispartofEnvironmental Mutagenesis and Genomics Society 50th Annual Meeting, EISSN:1098-2280, Vol. 60, S1 (2019); pp. 53spa
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/em.22328spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceEnvironmental Mutagenesis and Genomics Society 50th Annual Meetingspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPneumoconiosisspa
dc.subject.keywordRespiratory diseasespa
dc.subject.keywordFibrosisspa
dc.subject.keywordDiagnosisspa
dc.titleGenetic and epigenetic effects in a population of underground miners with coal workers Pneumoconiosisspa
dc.title.TranslatedTitleEfectos genéticos y epigenéticos en una población de mineros subterráneos con trabajadores del carbón Pneumoconiosisspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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