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Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults(2019) Ramírez-Vélez, Robinson; Hernández-Quiñones, Paula Andrea; Tordecilla Sanders, María Alejandra; Álvarez, Cristian; Ramírez-Campillo, Rodrigo; Izquierdo, Mikel; Correa Bautista, Jorge Enrique; Garcia-Hermoso, Antonio; Garcia, Ronald G.Background: Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases, such as cardiovascular disease (CVD), metabolic syndrome, and breast and colon cancers, and shortens life expectancy. We aimed to determine the effects of moderate (MCT)- versus high-intensity interval training (HIT) on vascular function parameters in physically inactive adults. We hypothesized that individualized HIT prescription would improve the vascular function parameters more than the MCT in a greater proportion of individuals. Methods: Twenty-one inactive adults were randomly allocated to receive either MCT group (60-75% of their heart rate reserve, [HRR] or HIT group (4 min at 85-95% of peak HRR), 3 days a week for 12 weeks. Vascular function (brachial artery flow-mediated dilation, FMD [%], normalized brachial artery flow-mediated dilation, FMDn [%], aortic pulse wave velocity, PWV [m·s - 1 ], AIx, augmentation index: aortic and brachial [%]), were measured at baseline and over 12 weeks of training. In order for a participant to be considered a responder to improvements in vascular function parameters (FMDn and PWV), the typical error was calculated in a favorable direction. Results: FMD changed by - 1.0% (SE 2.1, d = 0.388) in the MCT group, and + 1.8% (SE 1.8, d = 0.699) in the HIT group (no significant difference between groups: 2.9% [95% CI, - 3.0 to 8.8]. PWV changed by + 0.1 m·s - 1 (SE 0.2, d = 0.087) in the MCT group but decreased by - 0.4 m·s - 1 in the HIT group (SE 0.2, d = 0.497), with significant difference between groups: - 0.4 [95% CI, - 0.2 to - 0.7]. There was not a significant difference in the prevalence of no-responder for FMD (%) between the MCT and HIT groups (66% versus 36%, P = 0.157). Regarding PWV (m·s - 1 ), an analysis showed that the prevalence of no-responder was 77% (7 cases) in the MCT group and 45% (5 cases) in the HIT group (P = 0.114). Conclusions: Under the conditions of the present study, both groups experienced changed in vascular function parameters. Compared to MCT group, HIT is more efficacious for improving FMD and decreasing PWV, in physically inactive adults. Trial registration: ClinicalTrials.gov NCT02738385 registered on 23 March 2016. © 2019 The Author(s). - ÍtemAcceso AbiertoThe effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis(2016) Meneses-Echávez, Jose F; Correa-Bautista, Jorge E; González-Jiménez, Emilio; Schmidt Río-Valle, Jacqueline; Elkins, Mark R; Lobelo, Felipe; Ramírez-Vélez, RobinsonSeveral sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNF? (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. © 2016 American Association for Cancer Research.
- ÍtemAcceso AbiertoHealth-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. A pooled analysis(2019) Garcia-Hermoso, Antonio; Correa-Bautista, Jorge E.; Olloquequi, Jordi; Ramírez-Vélez, RobinsonObjective: The aim of this study was to investigate the relation between health-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. Method: The final sample consisted of 73,561 adolescents aged 13–15 years (35,175 girls) from Chile (n = 48,771) and Colombia (n = 24,790). Cardiorespiratory and musculoskeletal fitness were measured using 20-m shuttle run (relative peak oxygen uptake – VO2peak) and standing broad jump test (lower body explosive strength), respectively. The International Obesity Task Force definition was used to define weight status (i.e., underweight, normal weight, overweight, and obese). Results: The present study found an inverted J-shape relationship between body mass index, cardiorespiratory fitness, and musculoskeletal fitness in both genders and all age groups (p and lt; 0.01). Results also suggest that underweight adolescents, and not just overweight and obese adolescents, have lower odds of having a healthy cardiorespiratory fitness (based on new international criterion-referenced standards) profile when compared with their normal weight peers, except in girls aged 14 (p = 0.268) and 15 years (p = 0.280). Conclusions: The present results indicate low cardiorespiratory fitness and musculoskeletal fitness levels in underweight, overweight, and obese adolescents when compared with their normal weight peers. The findings appear to suggest that exercise programs should to decrease fat mass in overweight/obese adolescents and increase muscle mass in underweight adolescents. © 2018 Sociedade Brasileira de Pediatria
- ÍtemAcceso AbiertoUse of dietary supplements by pregnant women in Colombia(2018) Ramírez-Vélez, Robinson; Correa Bautista, Jorge Enrique; Triana Reina, Héctor Reynaldo; González-Jiménez, Emilio; Schmidt-Riovalle, Jacqueline; González-Ruíz, KatherineBackground: During pregnancy, the need for certain nutrients increases. This study assessed the prevalence and socio-demographic factors associated with dietary supplement use in a representative sample of pregnant women in Colombia. Method: Data for this study were obtained from a cross-sectional, nationally representative survey (ENSIN, 2010). A total of 1856 pregnant women, 13-49 years of age, were recruited. The use of prenatal dietary supplements (Vitamins A, C or E) was treated as a binary outcome (used at some time or never sued during pregnancy when prescribed by a doctor) in multinomial analyses. Sociodemographic data and associated factors were assessed by computer-assisted personal interview technology. Results: Of the sample, 1123 women (68.6%) reported taking prenatal dietary supplements at some stage during their pregnancy. Most users had a high socioeconomic level (79.5%), were in their third trimester of pregnancy (79.5%), were 30-49 years of age (74.0%), and lived in the central region of Colombia (73.8%). The multivariate logistic regression showed that third trimester of pregnancy (OR 6.2;95% CI 4.0 to 9.3), high educational level (OR 2.3; 95% CI 1.5 to 3.4), high socioeconomic level -SISBEN IV or more- (OR 2.0; 95% CI 1.4 to 2.8), residence in the Atlantic region (north) (OR 2.6; 95% CI 1.7 to 3.6), Eastern region (OR 2.0; 95% CI 1.3 to 3.1), central region (OR 2.6; 95% CI 1.7 to 3.9), Pacific region (west) (OR 1.5; 95% CI 1.0 to 2.3), and belonging to the mestizo (others) ethnic group (OR 1.2; 95% CI 1.0 to 2.6), were all associated with a higher probability of dietary supplement intake. Conclusion: The prevalence of prenatal dietary supplements in pregnant women in Colombia was found to be substantial. The variables significantly associated with their use were educational level, socioeconomic level, trimester of pregnancy, geographic level and ethnic group. These results indicate the necessity of implementing new health policies that guarantee uniform access to nutritional supplements for all population sectors, especially in countries, such as Colombia, who are currently undergoing a process of nutritional transition. © 2018 The Author(s).
ÍtemSolo MetadatosHandgrip Strength and Ideal Cardiovascular Health among Colombian Children and Adolescents(2016) Ramírez-Vélez, Robinson; Tordecilla Sanders, María Alejandra; Correa Bautista, Jorge Enrique; Peterson, Mark D.; Garcia-Hermoso, AntonioObjective To evaluate the association between handgrip strength and ideal cardiovascular health (CVH) in Colombian children and adolescents. Study design During the 2014-2015 school years, we examined a cross-sectional component of the FUPRECOL (Association for Muscular Strength with Early Manifestation of Cardiovascular Disease Risk Factors among Colombian Children and Adolescents) study. Participants included 1199 (n?=?627 boys) youths from Bogota (Colombia). Handgrip strength was measured with a standard adjustable hand held dynamometer and expressed relative to body mass (handgrip/body mass) and as absolute values in kilograms. Ideal CVH, as defined by the American Heart Association, was determined as meeting ideal levels of the following components: 4 behaviors (smoking status, body mass index, cardiorespiratory fitness, and diet) and 3 factors (total cholesterol, blood pressure, and glucose). Results Higher levels of handgrip strength (both absolute and relative values) were associated with a higher frequency of ideal CVH metrics in both sexes (P for trend ?.001). Also, higher levels of handgrip strength were associated with a greater number of ideal health behaviors (P for trend less than .001 in both boys and girls), and with a higher number of ideal health factors in boys (P for trend less than .001). Finally, levels of handgrip strength were similar between ideal versus nonideal glucose or total cholesterol groups in girls. Conclusions Handgrip strength was strongly associated with ideal CVH in Colombian children and adolescents, and thus supports the relevance of early targeted interventions to promote strength adaptation and preservation as part of primordial prevention. © 2016 Elsevier Inc.- ÍtemAcceso AbiertoExercise during pregnancy on maternal lipids: A secondary analysis of randomized controlled trial(2017) Ramírez-Vélez, Robinson; Lobelo, Felipe; Aguilar-de Plata, Ana C.; Izquierdo, Mikel; García-Hermoso, AntonioBackground: Today, scientific evidence has supported the popular belief that physical activity is associated with biological health in pregnant women. A randomized controlled trial was used to assess the benefits of physical exercise during pregnancy on maternal lipids in low-income Latina women. Methods: The study included 67 nulliparous low-income Latina women in gestational weeks 16-20, randomly assigned into one of two groups: 1) The exercise group, which took part in aerobic and resistance exercise for 60min, three times a week for 12weeks, 2) The control group, which undertook their usual physical activity and prenatal care. The primary outcomes were changes in maternal blood lipids after intervention. Obstetrical and neonatal outcomes measured were type of delivery, postpartum hemorrhage, newborn and/or maternal complications', gestational age, weight gain, birth weight, foetal growth, and Apgar score. Results: Fifty women completed the study. At the end of the intervention, there were differences between groups in low-density lipoprotein levels (mean change: -8mg/dL, 95%CI -3 to -29; P less than 0.001) and triglycerides (mean change: -6mg/dL, 95%CI -1 to -11; P=0.03). Also, compared with women who remained in the control group, active women showed lower complications during delivery (moderate postpartum haemorrhage) (58% compared with 75%; P less than 0.05) and lower complications in newborns (e.g. cyanosis or respiratory distress) (21% compared with 46%; P less than 0.001). Conclusions: An exercise programme during the second and third trimester favours less gain in low-density lipoprotein cholesterol and triglycerides fewer delivery and neonatal complications. Trial registration:NCT00741312(August 22, 2008). © 2017 The Author(s).
- ÍtemSolo MetadatosIdeal Cardiovascular Health and Incident Cardiovascular Disease Among Adults: A Systematic Review and Meta-analysis(2018) Ramírez-Vélez, Robinson; Saavedra, José M.; Lobelo, Felipe; Celis-Morales, Carlos A.; del Pozo-Cruz, Borja; García-Hermoso, AntonioObjective: To investigate the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) by conducting a systematic review and meta-analysis of prospective cohort studies. Methods: The MEDLINE, EMBASE, and CINAHL databases were searched from January 1, 2010, through July 31, 2017, for studies that met the following criteria: (1) prospective studies conducted in adults, (2) with outcome data on CVD incidence and (3) a measure of ideal CVH metrics. Results: Twelve studies (210,443 adults) were included in this analysis. Compared with adults who met 0 to 2 of the ideal CVH metrics (high-risk individuals), a significantly lower hazard for CVD incidence was observed in those who had 3 to 4 points for the ideal CVH metrics (hazard ratio [HR]=0.53; 95% CI, 0.47-0.59) and 5 to 7 points (HR=0.28; 95% CI, 0.23-0.33). Weaker associations were observed in studies with older individuals, suggesting that there is a positive relationship between age and HR. Conclusion: Although meeting 5 to 7 metrics is associated with the lowest hazard for CVD incidence, meeting 3 to 4 metrics still offers an important protective effect for CVD. Therefore, a realistic goal in the general population in the short term could be to promote at least an intermediate ideal CVH profile (3 to 4 metrics). © 2018 Mayo Foundation for Medical Education and Research
- ÍtemAcceso AbiertoRelationship between handgrip strength and muscle mass in female survivors of breast cancer: A mediation analysis(2017) Benavides-Rodríguez, Lorena; García-Hermoso, Antonio; Rodrigues-Bezerra, Diogo; Izquierdo, Mikel; Correa Bautista, Jorge Enrique; Ramírez-Vélez, RobinsonThis study explored the mediating factors of sarcopenia in a group of women survivors of breast cancer in Bogotá, Colombia. This was a descriptive cross-sectional study with 98 women survivors of breast cancer, who were registered with the SIMMON (Integrated Synergies to Improve Oncological Management in Colombia) Foundation. Body weight, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated. Body composition (percentage of fat and muscle mass) was evaluated via four-pole bioelectrical impedance analysis. Sarcopenia was defined as low muscle mass plus low grip strength or low gait speed (European Working Group on Sarcopenia in Older People (EWGSOP) criteria). A “causal” mediation analysis with the Baron and amp; Kenny procedure (PROCESS® macro, Columbus, OH, USA) was used to explore variables related to sarcopenia. Analyses were performed with the IBM SPSS 21 statistical package (SPSS Inc., Chicago, IL, USA). The significance level of the results obtained in the hypothesis contrast was p and lt; 0.05. The mean age of the sample was 65.5 ± 5.9 years, with a BMI of 27.8 ± 4.7 kg/m2. The prevalence of sarcopenia was 22.4%. Linear regression models suggest a partial mediation of anthropometric parameters (body mass, body mass index and waist circumference) in the association between handgrip strength and muscle mass. In conclusion, one in every five women survivors of breast cancer had sarcopenia. The findings seem to emphasize the importance of obesity prevention in women survivors of breast cancer, suggesting that high handgrip strength may not relate closely to greater muscle mass and therefore would not exclude the risk of sarcopenia. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- ÍtemAcceso AbiertoFerritin levels in pregnant Colombian women(2015) Ramírez-Vélez, Robinson; González-Ruíz, Katherine; Correa Bautista, Jorge Enrique; Martínez-Torres, Javier; Meneses-Echávez, José F; Rincon-Pabon, DavidObjective: Ferritin deficiency is associated with many adverse health outcomes and is highly prevalent worldwide. The present study assesses the prevalence and socio-demographic factors associated with ferritin deficiency in a representative sample of pregnant women in Colombia. Methods: We used data from the cross-sectional, nationally representative survey National Nutritional Survey (ENSIN, 2010). A total of 1,386, (13-49 years old) pregnant women were enrolled. Serum ferritin a concentration was determined by chemiluminescence and sociodemographic date (age, urbanicity geographic region, ethnicity and socioeconomic level-SISBEN), was assessed by computer-assisted personal interview technology. Multivariate analyses using unordered binomial logistic regression models were conducted in the main analysis. Results: The overall prevalence of ferritin deficiency (serum less than 12µg/L) was 37.2% (95% CI 35.0% to 39.2%). The multivariate logistic regression no shows associated with a probability of serum ferritin deficiencies. Conclusion: A significant prevalence of ferritin deficiency was found in our study population without an association with the studied sociodemographic factors. © 2015, Grupo Aula Medica S.A. All rights reserved.
- ÍtemSolo MetadatosWaist circumference distribution in Colombian schoolchildren and adolescents: The FUPRECOL Study(2016) Caicedo-Álvarez, Juan Carlos; Correa Bautista, Jorge Enrique; González-Jiménez, Emilio; Schmidt-RioValle, Jacqueline; Ramírez-Vélez, RobinsonObjective This study was intended to establish the percentile distribution of waist circumference in schoolchildren from Bogota, Colombia, participating in the FUPRECOL Study. Methods A cross-sectional study conducted in 3,005 children and 2,916 adolescents aged 9 to 17.9 years. Height, weight, waist circumference, hip circumference, and self-assessed sexual maturity status were recorded. Percentiles (3rd, 10th, 25th, 50th, 75th, 90th, and 97th) and smoothed sex- and age-specific curves were calculated, and the waist circumference values found were compared to international references from other ethnic populations. Results Fifty-seven percent of the overall population (n = 5,921) were females (mean age, 12.7 ± 2.3 years). In most age groups, waist circumference was greater in boys as compared to girls. The increase between the 50th and 97th percentiles by age was 15.7 cm in boys aged 9 to 9.9 years and 16.0 cm in girls aged 11-11.9 years. Comparison of our study results, by age group and sex, to international references showed that our 50th percentile was lower than reported in Peru and the UK except for studies in India, Venezuela (Merida), US, and Spain was higher. Conclusions Age- and sex-specific percentiles of waist circumference obtained from children and adolescents from Bogota, Colombia, are reported. They may be used as a reference both for nutritional assessment and for predicting cardiovascular risks at early ages. © 2016 SEEN
