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dc.creatorFeged-Rivadeneira, Alejandro 
dc.creatorÁngel, Andrés 
dc.creatorGonzález-Casabianca, Felipe 
dc.creatorRivera, Camilo 
dc.date.accessioned2019-02-15T16:36:43Z
dc.date.available2019-02-15T16:36:43Z
dc.date.created2018
dc.date.issued2018 
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19083
dc.descriptionDetermining the distribution of disease prevalence among heterogeneous populations at the national scale is fundamental for epidemiology and public health. Here, we use a combination of methods (spatial scan statistic, topological data analysis and epidemic profile) to study measurable differences in malaria intensity by regions and populations of Colombia. This study explores three main questions: What are the regions of Colombia where malaria is epidemic? What are the regions and populations in Colombia where malaria is endemic? What associations exist between epidemic outbreaks between regions in Colombia? Plasmodium falciparum is most prevalent in the Pacific Coast, some regions of the Amazon Basin, and some regions of the Magdalena Basin. Plasmodium vivax is the most prevalent parasite in Colombia, particularly in the Northern Amazon Basin, the Caribbean, and municipalities of Sucre, Antioquia and Cordoba. We find an acute peak of malarial infection at 25 years of age. Indigenous and Afrocolombian populations experience endemic malaria (with household transmission). We find that Plasmodium vivax decreased in the most important hotspots, often with moderate urbanization rate, and was re-introduced to locations with moderate but sustained deforestation. Infection by Plasmodium falciparum, on the other hand, steadily increased in incidence in locations where it was introduced in the 2009-2010 generalized epidemic. Our findings suggest that Colombia is entering an unstable transmission state, where rapid decreases in one location of the country are interconnected with rapid increases in other parts of the country. © 2018 Feged-Rivadeneira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLoS ONE, ISSN:1932-6203, Vol. 13 (2018)
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0203673&type=printable
dc.subjectArticle
dc.subjectColombia
dc.subjectControlled Study
dc.subjectDeforestation
dc.subjectDisease Classification
dc.subjectDisease Transmission
dc.subjectEndemic Disease
dc.subjectEpidemic
dc.subjectEthnicity
dc.subjectFemale
dc.subjectHuman
dc.subjectIncidence
dc.subjectMajor Clinical Study
dc.subjectMalaria
dc.subjectMalaria Falciparum
dc.subjectMale
dc.subjectNonhuman
dc.subjectPlasmodium Vivax Malaria
dc.subjectPopulation Research
dc.subjectUrbanization
dc.subjectWestern Hemisphere
dc.subject.ddcEnfermedades 
dc.subject.lembMalaria
dc.subject.lembPlasmodium
dc.subject.lembEpidemiología
dc.titleMalaria intensity in Colombia by regions and populations
dc.typearticle
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.source.bibliographicCitationRubio-Palis, Y., Zimmerman, R.H., Ecoregional classification of malaria vectors in the neotropics (1997) Journal of Medical Entomology, 34 (5), pp. 499-510. , https://doi.org/10.1093/jmedent/34.5.499, PMID: 9379453
dc.creator.googleFeged-Rivadeneira, Alejandro
dc.creator.googleÁngel, Andrés
dc.creator.googleGonzález-Casabianca, Felipe
dc.creator.googleRivera, Camilo
dc.identifier.doi10.1371/journal.pone.0203673


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