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dc.creatorEstrada, Victor H. Nieto 
dc.creatorFranco, Daniel L. Molano 
dc.creatorMoreno, Albert Alexander Valencia 
dc.creatorGambasica, Jose A. Rojas 
dc.creatorBornacelli, Yamil E. Jaller 
dc.creatorDel Valle, Anacaona Martinez 
dc.date.accessioned2020-06-11T13:22:02Z
dc.date.available2020-06-11T13:22:02Z
dc.date.created2015
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24997
dc.description.abstractIdiopathic peripartum cardiomyopathy presenting with heart failure is a true diagnostic and treatment challenge. Goal oriented clinical management aims at the relapse of left ventricular systolic dysfunction. A 35-year-old patient on her 12th day post-delivery presents progressive signs of heart failure. Transthoracic echocardiography showed severe mitral insufficiency, mild left ventricular dysfunction, mild tricuspid insufficiency, severe pulmonary hypertension, and right atrial enlargement. With wet and cold heart failure signs, the patient was a candidate for inodilator cardiovascular support and volume depletion therapy. As the patient presented a persistent tachycardia at rest, levosimendan was chosen over dobutamine. Levosimendan was administered at a dose of 0.2 g/kg/min during a period of 24 hours. After inodilator therapy, the patient's signs and symptoms of heart failure began to decrease, showing improvement of dyspnea, mitral murmur grade went from IV/IV to II/IV, filling pressures and systemic and pulmonary resistance indexes decreased, arterial blood gases improved, and an echocardiography performed 72 h later showed non-dilated cardiomyopathy, mild cardiac contractile dysfunction, mild mitral insufficiency, type I diastolic dysfunction and improvement of pulmonary hypertension. Cardiovascular function in peripartum cardiomyopathy tends to go back to normality in 23-41% of the cases, but in a large group of patients, severe ventricle dysfunction remains months after initial symptoms. This article describes the diagnostic process of a patient with peripartum cardiomyopathy and a successful reversion of a severe case of mitral insufficiency using levosimendan as a new therapeutic strategy in this clinical context.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Medicine Research, ISSN: , Vol.7, No.12 (2015); pp. 998-1001
dc.relation.urihttps://www.jocmr.org/index.php/JOCMR/article/download/2323/1314
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleReversion of Severe Mitral Insufficiency in Peripartum Cardiomyopathy Using Levosimendan
dc.typearticle
dc.publisherJournal of Clinical Medicine Research
dc.subject.keywordCardiorespiratory Medicine and Haematology
dc.subject.keywordMedical and Health Sciences
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.14740/jocmr2323w
dc.relation.citationEndPage1001
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage998
dc.relation.citationTitleJournal of Clinical Medicine Research
dc.relation.citationVolumeVol. 7


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