Show simple item record

dc.creatorCardenas, Paula P. 
dc.creatorSuarez, Carlos F. 
dc.creatorMartinez, Pilar 
dc.creatorPatarroyo, Manuel E. 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2020-08-06T16:21:11Z
dc.date.available2020-08-06T16:21:11Z
dc.date.created2005-01-15
dc.identifier.issnISSN: 0093-7711
dc.identifier.issnEISSN: 1432-1211
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26280
dc.description.abstractThe MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical research. Isolation, cloning and sequencing of exons 1–8 from 27 MHC class I alleles obtained from 13 individuals classified as belonging to three owl monkey species (A. nancymaae, A. nigriceps and A. vociferans) were carried out to establish similarities between Aotus MHC class I genes and those expressed by other New and Old World primates. Six Aotus MHC class I sequence groups (Ao-g1, Ao-g2, Ao-g3, Ao-g4, Ao-g5 and Ao-g6) weakly related to non-classical Catarrhini MHC were identified. An allelic lineage was also identified in one A. nancymaae and two A. vociferans monkeys, exhibiting a high degree of conservation, negative selection along the molecule and premature termination of the open reading frame at exon 5 (Ao-g5). These sequences’ high conservation suggests that they more likely correspond to a soluble form of Aotus MHC class I molecules than to a new group of processed pseudogenes. Another group, named Ao-g6, exhibited a strong relationship with Catarrhini’s classical MHC-B-C loci. Sequence evolution and variability analysis indicated that Aotus MHC class I molecules experience inter-locus gene conversion phenomena, contributing towards their high variability
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofImmunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.56, (January, 2005); pp.818-832
dc.relation.urihttps://link.springer.com/article/10.1007/s00251-004-0751-5
dc.sourceImmunogenetics
dc.titleMHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity
dc.typearticle
dc.publisherSpringer Nature
dc.subject.keywordAotus
dc.subject.keywordMHC class I molecules
dc.subject.keywordGene conversion
dc.subject.keywordEvolution
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1007/s00251-004-0751-5
dc.title.TranslatedTitleGenes MHC de clase I en el mono búho: organización mosaica, convergencia y diversidad de loci
dc.relation.citationEndPage832
dc.relation.citationStartPage818
dc.relation.citationTitleImmunogenetics
dc.relation.citationVolumeVol. 56
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record