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Functional, structural, and immunological compartmentalisation of malaria invasive proteins

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dc.creatorReyes, Claudiaspa
dc.creatorPatarroyo, Manuel Elkinspa
dc.creatorVargas, Luis Eduardospa
dc.creatorRodríguez, Luis Eduardospa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-08-06T16:20:16Z
dc.date.available2020-08-06T16:20:16Z
dc.date.created2007-03-09spa
dc.description.abstractConserved Plasmodium falciparum merozoite high activity binding peptides (HABPs) involved in red blood cell (RBC) invasion which are present in merozoite surface proteins (MSPs) involved in attachment, rolling over RBC, those derived from soluble proteins loosely bound to the membrane, and those present in microneme and rhoptry organelles have an ?-helical structure and bind with high affinity to HLA-DR52 molecules. On the contrary, conserved HABPs belonging to molecules anchored to the membrane by a GPI tail, or a transmembranal region, or those molecules presenting PEXEL motifs have a strand, turn or unordered configuration and bind with high affinity to HLA-DR53 molecules. Such functional, cellular, structural, and immunological compartmentalisation has tremendous implications in subunit-based, multi-epitope, synthetic, anti-malarial vaccine development.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2006.12.220
dc.identifier.issnISSN: 0006-291X
dc.identifier.issnEISSN: 1090-2104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25937
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage371
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage363
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 354
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.354, No.2 (2007); pp.363-371spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0006291X06028579spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiochemical and Biophysical Research Communicationsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMalariaspa
dc.subject.keywordInvasive proteinsspa
dc.subject.keywordCompartmentalisationspa
dc.subject.keywordStructurespa
dc.titleFunctional, structural, and immunological compartmentalisation of malaria invasive proteinsspa
dc.title.TranslatedTitleCompartimentación funcional, estructural e inmunológica de proteínas invasivas de la malaria.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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