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Prediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: Accuracy of the Framingham, SCORE, and UKPDS risk functions - The Hoorn Study

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dc.creatorvan der Heijden, Amber A.W.A.spa
dc.creatorOrtegon, Monica M.spa
dc.creatorNiessen, Louis W.spa
dc.creatorNijpels, Gielspa
dc.creatorDekker, Jacqueline M.spa
dc.date.accessioned2020-05-26T00:06:00Z
dc.date.available2020-05-26T00:06:00Z
dc.date.created2009spa
dc.description.abstractOBJECTIVE - To test the validity of the Framingham, Systematic Coronary Risk Evaluation (SCORE), and UK Prospective Diabetes Study (UKPDS) risk function in the prediction of risk of coronary heart disease (CHD) in populations with normal glucose tolerance (NGT), intermediate hyperglycemia, and type 2 diabetes. RESEARCH DESIGN AND METHODS - Calibration and discrimination of the three prediction models were tested using prospective data for 1,482 Caucasian men and women, 50-75 years of age, who participated in the Hoorn Study. All analyses were stratified by glucose status. RESULTS - During 10 years of follow-up, a total of 197 CHD events, of which 43 were fatal, were observed in this population, with the highest percentage of first CHD events in the diabetic group. The Framingham and UKPDS prediction models overestimated the risk of first CHD event in all glucose tolerance groups. Overall, the prediction models had a low to moderate discriminatory capacity. The SCORE risk function was the best predictor of fatal CHD events in the group with NGT (area under the receiver operating characteristic curve 0.79 [95% CI 0.70-0.87]), whereas the UKPDS performed better in the intermediate hyperglycemia group (0.84 [0.74-0.94]) in the estimation of fatal CHD risk. After exclusion of known diabetic patients, all prediction models had a higher discriminatory ability in the group with diabetes. CONCLUSIONS - The use of the Framingham function for prediction of the first CHD event is likely to overestimate an individual's absolute CHD risk. In CHD prevention, application of the SCORE and UKPDS functions might be useful in the absence of a more valid tool. © 2009 by the American Diabetes Association.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2337/dc09-0745
dc.identifier.issn0149-5992
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23848
dc.language.isoengspa
dc.relation.citationEndPage2098
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage2094
dc.relation.citationTitleDiabetes Care
dc.relation.citationVolumeVol. 32
dc.relation.ispartofDiabetes Care, ISSN: 0149-5992, Vol.32, No.11 (2009); pp. 2094-2098spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70449364536&doi=10.2337%2fdc09-0745&partnerID=40&md5=3afd3ba9931aec7835f0f8a4a54c53a7spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAccuracyspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordCalibrationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCoronary riskspa
dc.subject.keywordFatalityspa
dc.subject.keywordFollow upspa
dc.subject.keywordGlucose tolerance testspa
dc.subject.keywordHumanspa
dc.subject.keywordHyperglycemiaspa
dc.subject.keywordIschemic heart diseasespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordNon insulin dependent diabetes mellitusspa
dc.subject.keywordOutcome assessmentspa
dc.subject.keywordPopulation based case control studyspa
dc.subject.keywordRating scalespa
dc.subject.keywordReceiver operating characteristicspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordAgedspa
dc.subject.keywordBlood glucosespa
dc.subject.keywordCoronary diseasespa
dc.subject.keywordDiabetes complicationsspa
dc.subject.keywordDiabetes mellitus, type 2spa
dc.subject.keywordDiabetic angiopathiesspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow-up studiesspa
dc.subject.keywordGreat britainspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMassachusettsspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMulticenter studies as topicspa
dc.subject.keywordPrediabetic statespa
dc.subject.keywordReproducibility of resultsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordTime factorsspa
dc.titlePrediction of coronary heart disease risk in a general, pre-diabetic, and diabetic population during 10 years of follow-up: Accuracy of the Framingham, SCORE, and UKPDS risk functions - The Hoorn Studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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