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Juvenile polyautoimmunity in a rheumatology setting

dc.creatorMalagón C.spa
dc.creatorGomez M.D.P.spa
dc.creatorMosquera C.spa
dc.creatorVargas C.spa
dc.creatorGonzalez T.spa
dc.creatorArango C.spa
dc.creatorMartin L.spa
dc.creatorPerez P.spa
dc.creatorAmaya-Uribe L.spa
dc.creatorMolano González, Nicolásspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:05Z
dc.date.available2020-05-26T00:01:05Z
dc.date.created2019spa
dc.description.abstractOvert polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (? r = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA. © 2019eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2018.11.006
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23311
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage381
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage369
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 18
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.18, No.4 (2019); pp. 369-381spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063004565&doi=10.1016%2fj.autrev.2018.11.006&partnerID=40&md5=f4f7caddc31ee5a97ad8fb60e148b4a1spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntiphospholipid syndromespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordChildspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordFemalespa
dc.subject.keywordHashimoto diseasespa
dc.subject.keywordHumanspa
dc.subject.keywordIdiopathic thrombocytopenic purpuraspa
dc.subject.keywordJuvenile rheumatoid arthritisspa
dc.subject.keywordLocalized sclerodermaspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordQuestionnairespa
dc.subject.keywordReviewspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordVitiligospa
dc.subject.keywordAdolescentspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordClassificationspa
dc.subject.keywordClinical trialspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMulticenter studyspa
dc.subject.keywordOnset agespa
dc.subject.keywordPathologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordRheumatic diseasespa
dc.subject.keywordRheumatologyspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAge of onsetspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordChildspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordRetrospective studiesspa
dc.subject.keywordRheumatic diseasesspa
dc.subject.keywordRheumatologyspa
dc.subject.keywordSurveys and questionnairesspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmune tautologyspa
dc.subject.keywordJuvenile idiopathic arthritisspa
dc.subject.keywordJuvenile patientsspa
dc.subject.keywordPolyautoimmunityspa
dc.subject.keywordSystemic lupus erythematousspa
dc.titleJuvenile polyautoimmunity in a rheumatology settingspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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