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Infection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive review

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dc.creatorKivity, Shayespa
dc.creatorArango, Maria Teresaspa
dc.creatorEhrenfeld, Michaelspa
dc.creatorTehori, Omerspa
dc.creatorShoenfeld, Yehudaspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorAgmon-Levin, Nancyspa
dc.date.accessioned2020-05-25T23:55:54Z
dc.date.available2020-05-25T23:55:54Z
dc.date.created2014spa
dc.description.abstractSjögren's syndrome (SS) is an autoimmune disease characterized primarily by lymphocytic infiltration of the exocrine glands, and autoantibody production. Multiple environmental factors affecting an individual with a genetic susceptibility may trigger the development of SS. Herein, we aimed to evaluate links between the different pebbles in the mosaic of SS. Demographic, clinical data and blood samples were gathered from 82 consecutive patients with SS, and 139 healthy controls. Samples were analyzed for infectious serology and auto-antibodies as well as for relevant genetic mutations (TAP genes) and cytokines levels. An immune response (IgG) against Epstein-Barr virus (EBV) early antigen (EA) was positively associated with SS (OR 4; 95% CI: 1.82-8.83, p=0.001) while a protective effect of IgG anti-cytomegalovirus (CMV) was observed (OR 0.3; 95%CI: 0.16-0.74, p=0.009). Anti-Ro/SSA, anti-LA/SSB, anti-nuclear, anti-gliadin, anti-TTG-IgG and anti-RNP antibodies were statistically more prevalent among SS patients than controls. Notably, the presence of anti-Ro/SSA and anti La/SSB correlated with anti-EBVEA IgG (OR 3.1; 95%CI: 1.08-8.74) and (OR 3.9; 95%CI: 1.37-10.96) respectively. Autoantibodies, cytokines and several genetic markers correlated with clinical manifestation of SS. Our data suggest that infectious agents may play both a causative and protective role in the pathogenesis of SS. Moreover certain autoantibodies, cytokines and specific TAP alleles correlate with clinical manifestations of SS, and may enable better prediction and/or directed therapy once confirmed in future studies. © 2014 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2014.02.008
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22255
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage22
dc.relation.citationStartPage17
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 51
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.51,(2014); pp. 17-22spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84901282616&doi=10.1016%2fj.jaut.2014.02.008&partnerID=40&md5=256f3e62d24e765dee293eaf17de9175spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEpstein Barr virus antigenspa
dc.subject.keywordBacterialeng
dc.subject.keywordGliadin antibodyspa
dc.subject.keywordImmunoglobulin G antibodyspa
dc.subject.keywordRibonucleoprotein antibodyspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordBacterium antibodyspa
dc.subject.keywordImmunoglobulin Gspa
dc.subject.keywordProtozoon antibodyspa
dc.subject.keywordVirus antibodyspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBlood samplingspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCorrelational studyspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordDemographyspa
dc.subject.keywordEpstein Barr virusspa
dc.subject.keywordFemalespa
dc.subject.keywordGene mutationspa
dc.subject.keywordGenetic markerspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordInfectionspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMosaicismspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSerologyspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCase control studyspa
dc.subject.keywordComplicationspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordAdultspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntibodies Protozoaneng
dc.subject.keywordAntibodies Viraleng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordCross-Sectional Studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic Predisposition to Diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordImmunoglobulin Gspa
dc.subject.keywordInfectionspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordAuto-antibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGeneticsspa
dc.subject.keywordInfectionsspa
dc.subject.keywordSjögren's syndromespa
dc.titleInfection and autoimmunity in Sjogren's syndrome: A clinical study and comprehensive reviewspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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