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Mechanisms of genetically-based resistance to malaria

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dc.creatorLópez, Carolinaspa
dc.creatorSaravia, Carolinaspa
dc.creatorGomez, Andromedaspa
dc.creatorHoebeke, Johanspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:08:55Z
dc.date.available2020-05-26T00:08:55Z
dc.date.created2010spa
dc.description.abstractMalaria remains one of the most prevalent parasitoses worldwide. About 350 to 500. million febrile episodes are observed yearly in African children alone and more than 1. million people die because of malaria each year. Multiple factors have hampered the effective control of this disease, some of which include the complex biology of the Plasmodium parasites, their high polymorphism and their increasingly high resistance to antimalarial drugs, mainly in endemic regions. The ancient interaction between malarial parasites and humans has led to the fixation in the population of several inherited alterations conferring protection against malaria. Some of the mechanisms underlying protection against this disease are described in this review for hemoglobin-inherited disorders (thalassemia, sickle-cell trait, HbC and HbE), erythrocyte polymorphisms (ovalocytosis and Duffy blood group), enzymopathies (G6PD deficiency and PK deficiency) and immunogenetic variants (HLA alleles, complement receptor 1, NOS2, tumor necrosis factor-? promoter and chromosome 5q31-q33 polymorphisms). © 2010 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.gene.2010.07.008
dc.identifier.issn3781119
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24127
dc.language.isoengspa
dc.relation.citationEndPage12
dc.relation.citationIssueNo. 43862
dc.relation.citationStartPage1
dc.relation.citationTitleGene
dc.relation.citationVolumeVol. 467
dc.relation.ispartofGene, ISSN:3781119, Vol.467, No.43862 (2010); pp. 1-12spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77956880216&doi=10.1016%2fj.gene.2010.07.008&partnerID=40&md5=14f312804d8dbe371abb4704f6352cccspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordComplement component C3b receptorspa
dc.subject.keywordHemoglobin Cspa
dc.subject.keywordHemoglobin Espa
dc.subject.keywordInducible nitric oxide synthasespa
dc.subject.keywordLeukocyte antigenspa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordComplement receptorspa
dc.subject.keywordAllelespa
dc.subject.keywordAlpha thalassemiaspa
dc.subject.keywordBaboonspa
dc.subject.keywordChromosome 5qspa
dc.subject.keywordChromosome polymorphismspa
dc.subject.keywordElliptocytosisspa
dc.subject.keywordGene expressionspa
dc.subject.keywordHemoglobinopathyspa
dc.subject.keywordHumanspa
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSickle cellspa
dc.subject.keywordChemical structurespa
dc.subject.keywordErythrocytespa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGlucose 6 phosphate dehydrogenase deficiencyspa
dc.subject.keywordImmunologyspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordMalariaspa
dc.subject.keywordMetabolismspa
dc.subject.keywordSickle cell traitspa
dc.subject.keywordThalassemiaspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordGlucosephosphate Dehydrogenase Deficiencyspa
dc.subject.keywordHemoglobinopathiesspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunity, Innatespa
dc.subject.keywordMalariaspa
dc.subject.keywordModels, Molecularspa
dc.subject.keywordReceptors, Complementspa
dc.subject.keywordThalassemiaspa
dc.subject.keywordPlasmodium parasitesspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordGlucosephosphate Dehydrogenase Deficiencyspa
dc.subject.keywordHemoglobinopathiesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalariaspa
dc.subject.keywordPolymorphism, Geneticspa
dc.subject.keywordThalassemiaspa
dc.subject.keywordErythrocyte polymorphismspa
dc.subject.keywordHemoglobinopathyspa
dc.subject.keywordMalariaspa
dc.subject.keywordNatural resistancespa
dc.titleMechanisms of genetically-based resistance to malariaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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