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Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

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dc.creatorKarina Pastor-Sierraspa
dc.creatorLyda Espitia-Pérezspa
dc.creatorPedro Espitia-Pérezspa
dc.creatorAna Peñata-Tabordaspa
dc.creatorHugo Brangospa
dc.creatorClaudia Galeano-Páezspa
dc.creatorOsnamir Elías Bru-Corderospa
dc.creatorMarien Palma-Parraspa
dc.creatorSonia M. Díazspa
dc.creatorCarlos Trillosspa
dc.creatorLeonardo Briceñospa
dc.creatorÁlvaro J. Idrovospa
dc.creatorJuan Miranda-Pachecospa
dc.creatorEliana Téllezspa
dc.creatorLuisa Jiménez-Vidalspa
dc.creatorAndrés Coneo-Preteltspa
dc.creatorAlicia Humanez Álvarezspa
dc.creatorGean Arteaga-Arroyospa
dc.creatorDina Ricardo-Calderaspa
dc.creatorShirley Salcedo-Arteagaspa
dc.creatorMarcela Varona-Uribespa
dc.date.accessioned2024-01-31T18:29:29Z
dc.date.available2024-01-31T18:29:29Z
dc.date.created2023-11-25spa
dc.date.issued2023spa
dc.descriptionThe Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttp://doi.org/10.1016/j.scitotenv.2023.165789spa
dc.identifier.issn0048-9697spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/42142
dc.language.isoengspa
dc.publisherUniversidad del Rosariospa
dc.relation.urihttps://www.mdpi.com/2305-6304/11/10/821spa
dc.rightsAttribution 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.sourceScience of the Total Environmentspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectComplex mixturesspa
dc.subjectMontelibanospa
dc.subjectNechíspa
dc.subjectAranzazuspa
dc.subjectMicronuclei frequenciesspa
dc.subjectMining systemsspa
dc.titleMicronuclei frequency and exposure to chemical mixtures in three Colombian mining populationsspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
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