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Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter

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dc.creatorHerreño, Angélica Maríaspa
dc.creatorRamírez, Andrea Carolinaspa
dc.creatorChaparro, Viviana Paolaspa
dc.creatorFernandez, María Joséspa
dc.creatorCañas, Alejandraspa
dc.creatorMorantes, Carlos Fabianspa
dc.creatorMoreno, Olga Maríaspa
dc.creatorBrugés, Ricardo Eliasspa
dc.creatorMejía, Juan Andrésspa
dc.creatorBustos, Fernando Joséspa
dc.creatorMontecino, Martínspa
dc.creatorRojas, Adriana Pspa
dc.date.accessioned2020-05-26T00:01:45Z
dc.date.available2020-05-26T00:01:45Z
dc.date.created2019spa
dc.description.abstractLung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate. Unfortunately, diagnosis is established in advanced stages, where other tissues or organs can be affected. In recent years, lineage-specific transcription factors have been associated with a variety of cancers. One such transcription factor possibly regulating cancer is RUNX2, the master gene of early and late osteogenesis. In thyroid and prostate cancer, it has been reported that RUNX2 regulates expression of genes important in tumor cell migration and invasion. In this study, we report on RUNX2/p57 overexpression in 16 patients with primary non-small cell lung cancer and/or metastatic lung cancer associated with H3K27Ac at P1 gene promoter region. In some patients, H3K4Me3 enrichment was also detected, in addition to WDR5, MLL2, MLL4, and UTX enzyme recruitment, members of the COMPASS-LIKE complex. Moreover, transforming growth factor-? induced RUNX2/p57 overexpression and specific RUNX2 knockdown supported a role for RUNX2 in epithelial mesenchymal transition, which was demonstrated through loss of function assays in adenocarcinoma A549 lung cancer cell line. Furthermore, RUNX2 increased expression of epithelial mesenchymal transition genes VIMENTIN, TWIST1, and SNAIL1, which reflected increased migratory capacity in lung adenocarcinoma cells. © The Author(s) 2019.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1177/1010428319851014
dc.identifier.issn14230380
dc.identifier.issn10104283
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23401
dc.language.isoengspa
dc.publisherSAGE Publications Ltdspa
dc.relation.citationIssueNo. 5
dc.relation.citationTitleTumor Biology
dc.relation.citationVolumeVol. 41
dc.relation.ispartofTumor Biology, ISSN:14230380, 10104283, Vol.41, No.5 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85066436930&doi=10.1177%2f1010428319851014&partnerID=40&md5=d1cd2e85600458765f1798dacd753064spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCOMPASS LIKE complexspa
dc.subject.keywordEnzymespa
dc.subject.keywordHistone H3spa
dc.subject.keywordMessenger RNAspa
dc.subject.keywordMLL2 proteinspa
dc.subject.keywordMLL4 proteinspa
dc.subject.keywordTranscription factor RUNX2spa
dc.subject.keywordTranscription factor Snail1spa
dc.subject.keywordTransforming growth factor betaspa
dc.subject.keywordTwist related protein 1spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordUTX proteinspa
dc.subject.keywordVimentinspa
dc.subject.keywordWDR5 proteinspa
dc.subject.keywordRUNX2 protein, humanspa
dc.subject.keywordTranscription factor RUNX2spa
dc.subject.keywordTumor markerspa
dc.subject.keywordA-549 cell linespa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordCancer growthspa
dc.subject.keywordCell migrationspa
dc.subject.keywordClinical articlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordCorrelation analysisspa
dc.subject.keywordEnrichment culturespa
dc.subject.keywordEpigeneticsspa
dc.subject.keywordEpithelial mesenchymal transitionspa
dc.subject.keywordFemalespa
dc.subject.keywordGene controlspa
dc.subject.keywordGene functionspa
dc.subject.keywordGene knockdownspa
dc.subject.keywordGene lossspa
dc.subject.keywordGene overexpressionspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordLung adenocarcinoma cell linespa
dc.subject.keywordLung carcinogenesisspa
dc.subject.keywordLung metastasisspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordNon small cell lung cancerspa
dc.subject.keywordP57 genespa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordRUNX2 genespa
dc.subject.keywordSNAIL1 genespa
dc.subject.keywordTranscription regulationspa
dc.subject.keywordTWIST1 genespa
dc.subject.keywordVery elderlyspa
dc.subject.keywordVIMENTIN genespa
dc.subject.keywordApoptosisspa
dc.subject.keywordCase control studyspa
dc.subject.keywordCell motionspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordFollow upspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGenetic epigenesisspa
dc.subject.keywordGeneticsspa
dc.subject.keywordLung tumorspa
dc.subject.keywordMetabolismspa
dc.subject.keywordNon small cell lung cancerspa
dc.subject.keywordPathologyspa
dc.subject.keywordPrognosisspa
dc.subject.keywordSecondaryspa
dc.subject.keywordTumor cell culturespa
dc.subject.keywordTumor invasionspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAged, 80 and overspa
dc.subject.keywordApoptosisspa
dc.subject.keywordBiomarkers, Tumorspa
dc.subject.keywordCarcinoma, Non-Small-Cell Lungspa
dc.subject.keywordCase-Control Studiesspa
dc.subject.keywordCell Movementspa
dc.subject.keywordCell Proliferationspa
dc.subject.keywordCore Binding Factor Alpha 1 Subunitspa
dc.subject.keywordEpigenesis, Geneticspa
dc.subject.keywordEpithelial-Mesenchymal Transitionspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow-Up Studiesspa
dc.subject.keywordGene Expression Regulation, Neoplasticspa
dc.subject.keywordHumansspa
dc.subject.keywordLung Neoplasmsspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordNeoplasm Invasivenessspa
dc.subject.keywordPrognosisspa
dc.subject.keywordPromoter Regions, Geneticspa
dc.subject.keywordTumor Cells, Culturedspa
dc.subject.keywordEpigeneticspa
dc.subject.keywordEpithelial mesenchymal transitionspa
dc.subject.keywordHistonespa
dc.subject.keywordLung cancerspa
dc.subject.keywordRUNX2spa
dc.titleRole of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoterspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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