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Effect of disodium monofluorphosphate on plasma and blood viscosity in the rat

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dc.creatorDi Loreto V.spa
dc.creatorRigalli A.spa
dc.creatorCinara L.spa
dc.creatorHernández G.spa
dc.date.accessioned2020-05-26T00:04:23Z
dc.date.available2020-05-26T00:04:23Z
dc.date.created2008spa
dc.description.abstractAlpha macroglobulins (AM) are plasma proteins whose main function is to inactivate proteinases, protecting the tissues from the action of these enzymes. AM have influence on plasma viscosity (PV) and binds monofluorophosphate (MFP), which disturbs its homeostasis. The aim of this work was to evaluate whether the administration with MFP could modify blood viscosity. AM levels (?mol/l), PV (mPa·s), viscosity of red blood cells suspensions in NaCl 9 g/l (VES) and in autologue plasma (VEP) were measured in fifty-day old rats after a single dose of 80 ?mol MFP or after 30 days of treatment with 80 ?mol of MFP. Relative viscosity (RV) was calculated as the ratio VEP/PV. AM and PV increased significantly after 30 min of an oral dose of MFP. Controls (n=6), AM: 19.65±0.85, PV: 1.39±0.01, treated (n=6), AM: 22.88±0.75 (p less than 0.05), PV: 1.76±0.14 (p less than 0.05). After 30 days of treatment with MFP, AM and PV increased significantly. Controls (n=6), AM: 10.76±1.33, PV: 1.19±0.04, treated (n=6), AM: 17.66±1.27 (p less than 0.05), PV: 1.38±0.03 (p less than 0.05). The treatment with MFP modifies neither the VEP nor the RV. These results would indicate that AM and/or MFP did not interact with erythrocyte membrane and did not modify erythrocyte deformability. © 2008 - IOS Press and the authors. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3233/CH-2008-1135
dc.identifier.issn13860291
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23682
dc.language.isoengspa
dc.relation.citationEndPage265
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage259
dc.relation.citationTitleClinical Hemorheology and Microcirculation
dc.relation.citationVolumeVol. 40
dc.relation.ispartofClinical Hemorheology and Microcirculation, ISSN:13860291, Vol.40, No.4 (2008); pp. 259-265spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-58149381917&doi=10.3233%2fCH-2008-1135&partnerID=40&md5=ef5077fbf467c10637ea646434b9d0afspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAlpha 2 macroglobulinspa
dc.subject.keywordoraleng
dc.subject.keywordSodium chloridespa
dc.subject.keywordAnimal cellspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood viscosityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordErythrocytespa
dc.subject.keywordMalespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmaspa
dc.subject.keywordRatspa
dc.subject.keywordAdministrationeng
dc.subject.keywordAlpha-macroglobulinsspa
dc.subject.keywordAnimalsspa
dc.subject.keywordBlood viscosityspa
dc.subject.keywordBone density conservation agentsspa
dc.subject.keywordErythrocyte deformabilityspa
dc.subject.keywordFluoridesspa
dc.subject.keywordMalespa
dc.subject.keywordPhosphatesspa
dc.subject.keywordRatsspa
dc.subject.keywordBloodspa
dc.subject.keywordMacroglobulinspa
dc.subject.keywordMonofluorophosphatespa
dc.subject.keywordViscosityspa
dc.titleEffect of disodium monofluorphosphate on plasma and blood viscosity in the ratspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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