Ítem
Solo Metadatos

Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases.

Mostrar el registro sencillo de la publicación
dc.creatorReyes, Cesarspa
dc.creatorMolina-Franky, Jessicaspa
dc.creatorAza-Conde, Jorgespa
dc.creatorSuarez Martinez, Carlos Fernando
dc.creatorPabon, Lauraspa
dc.creatorMoreno-Vranich, Armandospa
dc.creatorPatarroyo, Manuel A.
dc.creatorPatarroyo, Manuel Espa
dc.date.accessioned2020-06-11T13:21:43Z
dc.date.available2020-06-11T13:21:43Z
dc.date.created2020spa
dc.description.abstractMalaria remains a large-scale public health problem, killing more than 400,000 people and infecting up to 230 million worldwide, every year. Unfortunately, despite numerous efforts and research concerning vaccine development, results to date have been low and/or strain-specific. This work describes a strategy involving Plasmodium falciparum Duffy binding-like (DBL) and reticulocyte-binding protein homologue (RH) family-derived minimum functional peptides, netMHCIIpan3.2 parental and modified peptides' in silico binding prediction and modeling some Aotus major histocompatibility class II (MHCII) molecules based on known human molecules' structure to understand their differences. These are used to explain peptides' immunological behaviour when used as vaccine components in the Aotus model. Despite the great similarity between human and Aotus immune system molecules, around 50% of Aotus allele molecules lack a counterpart in the human immune system which could lead to an Aotus-specific vaccine. It was also confirmed that functional Plasmodium falciparum' conserved proteins are immunologically silent (in both the animal model and in-silico prediction); they must therefore be modified to elicit an appropriate immune response. Some peptides studied here had the desired behaviour and can thus be considered components of a fully-protective antimalarial vaccine.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2020.05.025
dc.identifier.issn1090-2104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24880
dc.language.isoeng
dc.publisherElsevier Inc.spa
dc.relation.citationTitleBiochemical and biophysical research communications
dc.relation.ispartofBiochemical and biophysical research communications, ISSN:1090-2104 (2020); pp. -spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAotus animal modelspa
dc.subject.keywordDBL protein Familyspa
dc.subject.keywordMHCII binding Predictionspa
dc.subject.keywordMalariaspa
dc.subject.keywordPeptide-based vaccinespa
dc.subject.keywordRH protein familyspa
dc.titleMalaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos