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Differential expansion of the merozoite surface protein (msp)-7 gene family in Plasmodium species under a birth-and-death model of evolution

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dc.creatorGarzón-Ospina, Diegospa
dc.creatorCadavid, Luis F.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-25T23:57:10Z
dc.date.available2020-05-25T23:57:10Z
dc.date.created2010spa
dc.description.abstractMSP-7 is a surface protein expressed by the Plasmodium merozoite as part of a protein-complex involved in initial interaction between merozoite and erythrocyte. Contigs of seven Plasmodium species were analyzed in order to identify all msp-7 family genes. The search identified annotated and unannotated open reading frames (ORFs) and showed an uneven number of msp-7 genes among the different species of the Plasmodium lineage. A phylogenetic analysis established the presence of at least two ancestral genes and identified various lineage- and species-specific duplication events. An estimation of synonymous (dS) and non-synonymous substitutions (dN) showed higher dS values compared to dN values, suggesting the action of purifying selection on these genes, moreover no changes in ? (evolutive rates) were found in codon models test. These data together with the data obtained from the Gu's type-I functional divergence test and comparisons between evolutionary rates among orthologous and paralogous genes suggest functional redundancy. Finally, an analysis of recombination events suggests that several sequences are undergoing such process and that this mechanism could therefore be playing an important role in the emergence of new sequences. We conclude that evolution of the msp-7 family is in agreement with a birth-and-death model of evolution, as msp-7 genes have expanded until reaching an optimal gene copy number in each Plasmodium species in order to adapt to different niches. © 2010 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.ympev.2010.02.017
dc.identifier.issn10959513
dc.identifier.issn10557903
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22623
dc.language.isoengspa
dc.relation.citationEndPage408
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage399
dc.relation.citationTitleMolecular Phylogenetics and Evolution
dc.relation.citationVolumeVol. 55
dc.relation.ispartofMolecular Phylogenetics and Evolution, ISSN:10959513, 10557903, Vol.55, No.2 (2010); pp. 399-408spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77950043187&doi=10.1016%2fj.ympev.2010.02.017&partnerID=40&md5=1592c9088e2d14d798d80b4e199bbf6fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordgeneticeng
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordArticlespa
dc.subject.keywordBiological modelspa
dc.subject.keywordClassificationspa
dc.subject.keywordCodonspa
dc.subject.keywordContig mappingspa
dc.subject.keywordDna sequencespa
dc.subject.keywordGenetic selectionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordMultigene familyspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordSequence alignmentspa
dc.subject.keywordSpecies differencespa
dc.subject.keywordCodonspa
dc.subject.keywordContig mappingspa
dc.subject.keywordEvolutioneng
dc.subject.keywordMembrane proteinsspa
dc.subject.keywordModelseng
dc.subject.keywordMultigene familyspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSelectioneng
dc.subject.keywordSequence alignmentspa
dc.subject.keywordSequence analysiseng
dc.subject.keywordSpecies specificityspa
dc.subject.keywordFunctional redundancyspa
dc.subject.keywordGene duplicationspa
dc.subject.keywordMsp-7spa
dc.subject.keywordMultigene familyspa
dc.subject.keywordPlasmodiumspa
dc.titleDifferential expansion of the merozoite surface protein (msp)-7 gene family in Plasmodium species under a birth-and-death model of evolutionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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