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Th1/Th2 cytokines in patients with systemic lupus erythematosus: Is tumor necrosis factor ? protective?

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dc.creatorGómez, Dianaspa
dc.creatorCorrea, Paula A.spa
dc.creatorGómez, Luis Miguelspa
dc.creatorCadena, Joséspa
dc.creatorMolina, José F.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-08-19T14:40:50Z
dc.date.available2020-08-19T14:40:50Z
dc.date.created2004-06spa
dc.description.abstractObjectives: To determine the circulating levels of Th1 and Th2 cytokines in patients with systemic lupus erythematosus (SLE) and to elucidate their association with disease activity and autoimmune response.MethodsWe included 52 patients and 25 healthy controls. Serum levels of tumor necrosis factor (TNF) ?, interferon (IFN) ?, interleukin (IL)-12p70, IL-10, and IL-4, as well as anti-DNA, -Ro, -La, -RNP, and -Sm antibodies were determined by enzyme-linked immunosorbent assay. Disease activity was recorded according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and classified as very active (SLEDAI ? 13), moderately active (SLEDAI: 3–12), or inactive (SLEDAI ? 2).ResultsThe mean age of the patients was 34.2 ± 12.6 years, and the mean duration of disease was 4.9 ± 7.6 years. Twelve patients (23%), 20 patients (34.5%), and 20 patients (34.5%) had highly, moderately, and inactive SLE, respectively. Levels of IFN-?, TNF-?, and IL-12 were significantly higher in patients than in healthy controls (P < .03), as well as the IL-12/IL-10, IL-12/IL-4, IFN/IL-10, IFN/IL-4, TNF/IL-10, and TNF/IL-4 ratios (P < .01), suggesting a major participation of Th1 over Th2 cytokines. Nevertheless, a direct correlation between Th1 (IFN-? and TNF-?) and Th2 (IL-4 and IL-10) cytokines was observed in patients (r > .5, P < .01), indicating a mutual Th1-Th2 participation. TNF-? levels and the TNF/IL-10 ratio were higher in patients with inactive disease compared with patients with very active disease and controls (P < .04). IL-12 levels and IL-12/IL-4, as well as IL-12/IL-10, ratios were higher in patients with very active disease than in those with inactive SLE and controls (P < .01). IL-10 levels were associated with anti-DNA, anti-Ro, and anti-La response (P < .01).ConclusionOur results suggest that TNF-? could be a protective factor in SLE patients, whereas IL-12p70 participates in disease activity and IL-10 influences the autoimmune response (autoantibody production).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.semarthrit.2003.11.002
dc.identifier.issnISSN: 0049-0172
dc.identifier.issnEISSN: 1532-866X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27041
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage413
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage404
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 33
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol., 33 No.6 (2004); pp. 404-413spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017203002142spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceSeminars in Arthritis and Rheumatismspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordCytokinesspa
dc.subject.keywordTNF-?spa
dc.subject.keywordIL-10IL12spa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordSLEDAIspa
dc.titleTh1/Th2 cytokines in patients with systemic lupus erythematosus: Is tumor necrosis factor ? protective?spa
dc.title.TranslatedTitleCitocinas Th1 / Th2 en pacientes con lupus eritematoso sistémico: ¿es protector el factor de necrosis tumoral ??spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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