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Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families

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dc.creatorAggarwal, Rachna
dc.creatorAnaya, Juan-Manuel
dc.creatorKoelsch, Kristi A.
dc.creatorKurien, Biji T.
dc.creatorScofield, R. Hal
dc.creator.googleAggarwal, Rachnaspa
dc.creator.googleAnaya, Juan-Manuelspa
dc.creator.googleKoelsch, Kristi A.spa
dc.creator.googleKurien, Biji T.spa
dc.creator.googleScofield, R. Halspa
dc.date.accessioned2020-04-18T04:33:44Z
dc.date.available2020-04-18T04:33:44Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractSystemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease. © 2015 Rachna Aggarwal et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/298506
dc.identifier.issn2090-0422
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21680
dc.language.isoengspa
dc.relation.citationTitleAutoimmune Diseases
dc.relation.citationVolumeVol. 2015
dc.relation.ispartofAutoimmune Diseases, ISSN: 2090-0422 Vol. 2015, (2015)spa
dc.relation.urihttps://www.hindawi.com/journals/ad/2015/298506/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectautoantibodyspa
dc.subjectcohort analysisspa
dc.subjectmajor clinical studyspa
dc.subjectmalespa
dc.subjectpriority journalspa
dc.subjectSerologíaspa
dc.subjectSindrome de Sjoegrenspa
dc.subjectLupus eritematosospa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordcontrolled studyspa
dc.subject.keyworddisease associationspa
dc.subject.keywordfemalespa
dc.subject.keywordhumanspa
dc.subject.keywordrisk assessmentspa
dc.subject.lembLupus eritematoso sistémicospa
dc.subject.lembSíndrome de Sjögrenspa
dc.subject.lembEnfermedades del sistema inmunológicospa
dc.titleAssociation between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Familiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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