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Changing ABRA protein peptide to fit into the HLA-DRbeta1*0301 molecule renders it protection-inducing
| dc.creator | Salazar, Luz M. | spa |
| dc.creator | Alba, Martha P. | spa |
| dc.creator | Curtidor, Hernando | spa |
| dc.creator | Bermudez, Adriana | |
| dc.creator | Vargas, Luis E. | spa |
| dc.creator | Rivera, Zuly J. | spa |
| dc.creator | Patarroyo, Manuel E. | spa |
| dc.date.accessioned | 2020-08-06T16:20:30Z | |
| dc.date.available | 2020-08-06T16:20:30Z | |
| dc.date.created | 2004-09-10 | spa |
| dc.description.abstract | The Plasmodium falciparum acidic–basic repeat antigen represents a potential malarial vaccine candidate. One of this protein’s high activity binding peptides, named 2150 (161KMNMLKENVDYIQKNQNLFK180), is conserved, non-immunogenic, and non-protection-inducing. Analogue peptides whose critical binding residues (in bold) were replaced by amino-acids having similar mass but different charge were synthesized and tested to try to modify such immunological properties. These analogues’ HLA-DR?1* molecule binding ability were also studied in an attempt to explain their biological mechanisms and correlate binding capacity and immunological function with their three-dimensional structure determined by 1H NMR. A 310 distorted helical structure was identified in protective and immunogenic peptide 24922 whilst ?-helical structure was found for non-immunogenic, non-protective peptides having differences in ?-helical position. The changes performed on immunogenic, protection-inducing peptide 24922 allowed it to bind specifically to the HLA-DR?1*0301 molecule, suggesting that these changes may lead to better interaction with the MHC Class II-peptide-TCR complex rendering it immunogenic and protective, thus suggesting a new way of developing multi-component, sub-unit-based anti-malarial vaccines. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.doi | https://doi.org/10.1016/j.bbrc.2004.07.086 | |
| dc.identifier.issn | ISSN: 0006-291X | |
| dc.identifier.issn | EISSN: 1090-2104 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/26036 | |
| dc.language.iso | eng | spa |
| dc.publisher | Elsevier | spa |
| dc.relation.citationEndPage | 125 | |
| dc.relation.citationIssue | No. 1 | |
| dc.relation.citationStartPage | 119 | |
| dc.relation.citationTitle | Biochemical and Biophysical Research Communications | |
| dc.relation.citationVolume | Vol. 332 | |
| dc.relation.ispartof | Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.332, No.1 (2004); pp.119-125 | spa |
| dc.relation.uri | https://www.sciencedirect.com/science/article/abs/pii/S0006291X04015803?via%3Dihub | spa |
| dc.rights.accesRights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.acceso | Restringido (Acceso a grupos específicos) | spa |
| dc.source | Biochemical and Biophysical Research Communications | spa |
| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject.keyword | ABRA protein | spa |
| dc.subject.keyword | Peptide analogues | spa |
| dc.subject.keyword | Vaccine candidate | spa |
| dc.subject.keyword | Malaria | spa |
| dc.subject.keyword | Conformation | spa |
| dc.subject.keyword | NMR | spa |
| dc.title | Changing ABRA protein peptide to fit into the HLA-DRbeta1*0301 molecule renders it protection-inducing | spa |
| dc.title.TranslatedTitle | Cambiar el péptido de la proteína ABRA para que se ajuste a la molécula HLA-DRbeta1 * 0301 hace que induzca la protección | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
