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Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

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dc.creatorLin, C Pspa
dc.creatorAdrianto, Ispa
dc.creatorLessard, C Jspa
dc.creatorKelly, J Aspa
dc.creatorKaufman, K Mspa
dc.creatorGuthridge, J Mspa
dc.creatorFreedman, B Ispa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorAlarcón-Riquelme, M Espa
dc.creatorPons-Estel, B Aspa
dc.creatorMartin, Jspa
dc.creatorGlenn, Sspa
dc.creatorAdler, Aspa
dc.creatorBae, S-Cspa
dc.creatorPark, S-Yspa
dc.creatorBang, S-Yspa
dc.creatorSong, Y-Wspa
dc.creatorBoackle, S Aspa
dc.creatorBrown, E Espa
dc.creatorEdberg, J Cspa
dc.creatorAlarcón, G Sspa
dc.creatorPetri, M Aspa
dc.creatorCriswell, L Aspa
dc.creatorRamsey-Goldman, Rspa
dc.creatorReveille, J Dspa
dc.creatorVila, L Mspa
dc.creatorGilkeson, G Sspa
dc.creatorKamen, D Lspa
dc.creatorZiegler, Jspa
dc.creatorJacob, C Ospa
dc.creatorRasmussen, Aspa
dc.creatorJames, J Aspa
dc.creatorKimberly, R Pspa
dc.creatorMerrill, J Tspa
dc.creatorNiewold, T Bspa
dc.creatorScofield, R Hspa
dc.creatorStevens, A Mspa
dc.creatorTsao, B Pspa
dc.creatorVyse, T Jspa
dc.creatorLangefeld, C Dspa
dc.creatorMoser, K Lspa
dc.creatorHarley, J Bspa
dc.creatorGaffney, P Mspa
dc.creatorMontgomery, C Gspa
dc.date.accessioned2020-05-26T00:09:03Z
dc.date.available2020-05-26T00:09:03Z
dc.date.created2012spa
dc.description.abstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P and lt;2.03 × 10 -3 were observed between LN and MYH9 in EAs (N=4620), with the most pronounced association at rs2157257 (P=4.7 × 10 -4, odds ratio (OR)=1.205). A modest effect with MYH9 was also detected in Gullah (rs8136069, P=0.0019, OR=2.304). No association between LN and MYH9 was found in AAs, Asians, Amerindians or Hispanics. This study provides the first investigation of MYH9 in LN in non-Africans and of APOL1 in LN in any population, and presents novel insight into the potential role of MYH9 in LN in EAs. © 2012 Macmillan Publishers Limited All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/gene.2011.82
dc.identifier.issn14664879
dc.identifier.issn14765470
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24135
dc.language.isoengspa
dc.relation.citationEndPage238
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage232
dc.relation.citationTitleGenes and Immunity
dc.relation.citationVolumeVol. 13
dc.relation.ispartofGenes and Immunity, ISSN:14664879, 14765470, Vol.13, No.3 (2012); pp. 232-238spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84859913345&doi=10.1038%2fgene.2011.82&partnerID=40&md5=51e238add0eb23001d1592d389d271a4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApolipoproteinspa
dc.subject.keywordhdleng
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordApolipoprotein l 1spa
dc.subject.keywordMyosin heavy chainspa
dc.subject.keywordMyosin heavy chain 9spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAfrican americanspa
dc.subject.keywordAmerican indianspa
dc.subject.keywordArticlespa
dc.subject.keywordAsianspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEuropean americanspa
dc.subject.keywordHispanicspa
dc.subject.keywordHumanspa
dc.subject.keywordLupus erythematosus nephritisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordAfrican americansspa
dc.subject.keywordApolipoproteinsspa
dc.subject.keywordEuropean continental ancestry groupspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordLinkage disequilibriumspa
dc.subject.keywordLipoproteinseng
dc.subject.keywordLupus nephritisspa
dc.subject.keywordMolecular motor proteinsspa
dc.subject.keywordMyosin heavy chainsspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordApol1spa
dc.subject.keywordLupus nephritisspa
dc.subject.keywordMultiethnic association studyspa
dc.subject.keywordMyh9spa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleRole of MYH9 and APOL1 in African and non-African populations with lupus nephritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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